Tumor suppressor activity of CBX7 in lung carcinogenesis. (Articolo in rivista)

Type
Label
  • Tumor suppressor activity of CBX7 in lung carcinogenesis. (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Forzati F, Federico A, Pallante P, Fedele M, Fusco A. (2012)
    Tumor suppressor activity of CBX7 in lung carcinogenesis.
    in Cell cycle (Georget. Tex.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Forzati F, Federico A, Pallante P, Fedele M, Fusco A. (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli Federico II, Naples, Italy. (literal)
Titolo
  • Tumor suppressor activity of CBX7 in lung carcinogenesis. (literal)
Abstract
  • The generation of knockout mice for the Cbx7 gene validates the tumor suppressor role of CBX7, whose expression is lost in several human malignancies. Indeed, these mice developed liver and lung adenomas and carcinomas. Cyclin E overexpression due to the lack of Cbx7 negative regulation of its expression likely accounts for the phenotype of the Cbx7-KO mice. A similar mechanism is likely involved in human lung carcinogenesis, since cyclin E upregulation associated with the loss of CBX7 expression has been observed in most of the human lung carcinomas analyzed. (literal)
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