http://www.cnr.it/ontology/cnr/individuo/prodotto/ID206190
Interleukin-8 induces lymphocyte chemotaxis into the pleural space role of pleural macrophages (Articolo in rivista)
- Type
- Label
- Interleukin-8 induces lymphocyte chemotaxis into the pleural space role of pleural macrophages (Articolo in rivista) (literal)
- Anno
- 1999-01-01T00:00:00+01:00 (literal)
- Alternative label
Pace E, Gjomarkaj M, Melis, M, Profita M, Spatafora M, Vignola A M, Bonsignore G, Mody CH (1999)
Interleukin-8 induces lymphocyte chemotaxis into the pleural space role of pleural macrophages
in American journal of respiratory and critical care medicine; American Thoracic Society, New York (Stati Uniti d'America)
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- Pace E, Gjomarkaj M, Melis, M, Profita M, Spatafora M, Vignola A M, Bonsignore G, Mody CH (literal)
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- Ist. di Fisiopatologia Respiratoria, Consiglio Nazionale delle Ricerche, Via Trabucco, 180, 90146 Palermo, Italy (literal)
- Titolo
- Interleukin-8 induces lymphocyte chemotaxis into the pleural space role of pleural macrophages (literal)
- Abstract
- The pleural space is a potential compartment between the lung and chest wall that becomes filled with fluid and inflammatory cells in a number of respiratory diseases. In an attempt to understand one aspect of the inflammatory process in the pleural space, we compared the responses in three different diseases (congestive heart failure [CHF], tuberculosis [TB], and cancer). Large concentrations of interleukin-8 (IL-8) were detected in cancer and TB effusions, but not in CHF. Surprisingly, the concentration of IL-8 correlated best with lymphocyte recruitment and not with neutrophil recruitment. Pleural fluid from cancer and TB patients was chemotactic for lymphocytes, and this activity was partly blocked by an anti-IL-8 antibody in cancer and completely blocked in TB. To determine whether there was the potential for a chemotactic gradient into the pleural space, pleural effusion cells were analyzed for the expression of IL-8. Cells in the effusions of cancer patients expressed IL-8, whereas IL-8 could not be detected from the cells of TB and CHF effusions. To explore the possible role of pleural macrophages in the regulation of IL-8, pleural effusion cells were treated with culture supernatants from stimulated pleural macrophages. Stimulated pleural macrophages were able to induce expression of messenger RNA (mRNA) for IL-8 and IL-8 protein production, and this activity was abrogated by blocking tumor necrosis factor-alpha. These findings suggest that soluble IL-8 is an important factor for the recruitment of lymphocytes into the pleural space, and that this cytokine is produced by both pleural structural and cancer cells after their activation by macrophage-derived, cytokine-mediated signals. (literal)
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