Contrasting effects of IFNalfa on MHC class II expression in professional vs. nonprofessional APCs: Role of CIITA type IV promoter (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Contrasting effects of IFNalfa on MHC class II expression in professional vs. nonprofessional APCs: Role of CIITA type IV promoter (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.rinim.2012.09.001 (literal)

Alternative label

• Pisapia L, Del Pozzo G, Barba P, Citro A, Harris P.E, Maffei A. (2012)
  Contrasting effects of IFNalfa on MHC class II expression in professional vs. nonprofessional APCs: Role of CIITA type IV promoter
  in Results in Immunology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Pisapia L, Del Pozzo G, Barba P, Citro A, Harris P.E, Maffei A. (literal)

Pagina inizio

• 174 (literal)

Pagina fine

• 183 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 2 (literal)

Rivista

• Results in Immunology (Rivista)

Note

• Scopus (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples, Italy Department of Medicine of Columbia University Medical Center, New York, NY, USA (literal)

Titolo

• Contrasting effects of IFNalfa on MHC class II expression in professional vs. nonprofessional APCs: Role of CIITA type IV promoter (literal)

Abstract

• We previously demonstrated that, in ex vivo cultures, IFN? downregulates the expression of MHC class II (MHCII) genes in human non-professional APCs associated with pancreatic islets. IFN? has an opposing effect on MHCII expression in professional APCs. In this study, we found that the mechanism responsible for the IFN?-mediated MHCII's downregulation in human MHCII-positive non-professional antigen presenting human non-hematopoietic cell lines is the result of the negative feedback system that regulates cytokine signal transduction, which eventually inhibits promoters III and IV of CIITA gene. Because the CIITA-PIV isoform is mostly responsible for the constitutive expression of MHCII genes in non-professional APCs, we pursued and achieved the specific knockdown of CIITA-PIV mRNA in our in vitro system, obtaining a partial silencing of MHCII molecules similar to that obtained by IFN?. We believe that our results offer a new understanding of the potential significance of CIITA-PIV as a therapeutic target for interventional strategies that can manage autoimmune disease and allograft rejection with little interference on the function of professional APCs of the immune system. (literal)

Prodotto di

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Analisi cellulare e molecolare della risposta immunitaria indotta da vaccini sintetici (SV.P15.009.001) (Modulo)

Autore CNR

• ANTONELLA MAFFEI (Persona)
• LAURA PISAPIA (Unità di personale esterno)
• GIOVANNA DEL POZZO (Unità di personale interno)
• PASQUALE BARBA (Persona)

Insieme di parole chiave

• Keywords of "Contrasting effects of IFNalfa on MHC class II expression in professional vs. nonprofessional APCs: Role of CIITA type IV promoter" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Analisi cellulare e molecolare della risposta immunitaria indotta da vaccini sintetici (SV.P15.009.001) (Modulo)

Autore CNR di

• GIOVANNA DEL POZZO (Unità di personale interno)
• LAURA PISAPIA (Unità di personale esterno)
• PASQUALE BARBA (Persona)
• ANTONELLA MAFFEI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Results in Immunology (Rivista)

Insieme di parole chiave di

• Keywords of "Contrasting effects of IFNalfa on MHC class II expression in professional vs. nonprofessional APCs: Role of CIITA type IV promoter" (Insieme di parole chiave)