3C-SiC nanowires functionalized with porphyrins by supersonic molecular beams for photodynamic therapy (Abstract/Comunicazione in atti di convegno)

Type
Label
  • 3C-SiC nanowires functionalized with porphyrins by supersonic molecular beams for photodynamic therapy (Abstract/Comunicazione in atti di convegno) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • L. Aversa, R. Tatti, R. Verucchi, F. Fabbri, F. Rossi, M. Bosi, S. Iannotta (2011)
    3C-SiC nanowires functionalized with porphyrins by supersonic molecular beams for photodynamic therapy
    in 20. congresso nazionale AIV : Energia e materiali: tecnologie a confronto e prospettive, Padova, 17 - 19 maggio 2011
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • L. Aversa, R. Tatti, R. Verucchi, F. Fabbri, F. Rossi, M. Bosi, S. Iannotta (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • ID_PUMA: cnr.imem.tn/2011-B6-001 (literal)
Note
  • Abstract (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • IMEM-CNR Istituto dei Materiali per l'Elettronica ed il Magnetismo-Povo(Trento), Italy ; IMEM-CNR Istituto dei Materiali per l'Elettronica ed il Magnetismo- Parma, Italy (literal)
Titolo
  • 3C-SiC nanowires functionalized with porphyrins by supersonic molecular beams for photodynamic therapy (literal)
Abstract
  • Silicon Carbide (SiC) is a wide band-gap semiconductor that exhibits superior chemical-physical properties, making it well suitable for applications in several fields. The 3C-SiC polytype has been proved to be a biocompatible material: a promising candidate for bio-medical devices. Nano-sized 3C-SiC structures, such as SiC nanowires (NWs), can show interesting light emission properties, a phenomenon mainly attributed to either surface states or quantum confinement effects. It is promising the idea to couple this light emission with an organic absorber showing strong fluorescence properties, a viable route to increase the optical emission efficiency as well as to promote the anchoring of biological groups. Modification of the inorganic semiconductor surface with organic or bio-molecules also represents the route to activate processes at the interface such as biomolecular recognition and adhesion of species of biological interest. This can be achieved by functionalizing the SiC NWs with porphyrins, a class of macrocycle molecules showing a good match between the organic absorption Q band and the 3C-SiC near-band-edge-optical emission. A possible application for such a system is for cancer treatment: the 3C-SiC emission can be used to activate the singlet oxygen production by porphyrins, the dominant cytotoxic agent produced during photodynamic therapy (PDT). We demonstrated the functionalization of SiC/SiO2 core shell NWs, grown by a carbothermal method, showing enhanced fluorescence, with fluorinated porphyrins H2TPP(F) by supersonic molecular beam deposition (SuMBD), an approach that can promote and activate chemical/physical processes at the interface by means of the organic precursor kinetics properties. The H2TPP(F)/SiC-NWs system has been investigated in-situ with surface photoelectron spectroscopy at ELETTRA Synchrotron (Trieste-Italy) and ex-situ by Cathodoluminescence(CL). Analysis revealed the NWs shell structure, giving rise to the SiC luminescence, while the interface was characterized by a strong interaction between fluorine and the oxidized layer. Results concerning the core level (C1s, Si2p, N1s, F1s) and CL analysis of clean and functionalized NWs will be presented. (literal)
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