Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data. (Articolo in rivista)

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  • Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data. (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1371/journal.pone.0054289 (literal)
Alternative label
  • Biino G, Santimone I, Minelli C, Sorice R, Frongia B, Traglia M, Ulivi S, Di Castelnuovo A, Gögele M, Nutile T, Francavilla M, Sala C, Pirastu N, Cerletti C, Iacoviello L, Gasparini P, Toniolo D, Ciullo M, Pramstaller P, Pirastu M, de Gaetano G, Balduini CL. (2013)
    Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data.
    in PloS one
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Biino G, Santimone I, Minelli C, Sorice R, Frongia B, Traglia M, Ulivi S, Di Castelnuovo A, Gögele M, Nutile T, Francavilla M, Sala C, Pirastu N, Cerletti C, Iacoviello L, Gasparini P, Toniolo D, Ciullo M, Pramstaller P, Pirastu M, de Gaetano G, Balduini CL. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 8(1) (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • e54289 (literal)
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  • Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy Institute of Population Genetics, National Research Council of Italy, Sassari, Italy Laboratory of Genetic and Environmental Epidemiology, Research Laboratories, Fondazione di Ricerca e Cura \"Giovanni Paolo II\", Università Cattolica. Campobasso, Italy Institute of Genetic Medicine, EURAC Research, Bolzano, Italy Institute of Genetics and Biophysics A. Buzzati-Traverso, National Research Council of Italy, Naples, Italy Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy Institute for Maternal and Child Health - IRCCS \"Burlo Garofolo\" - Trieste, Italy Medical Genetics, Department of Reproductive Sciences, University of Trieste, Trieste, Italy Laboratory of Cell Biology and Pharmacology of Thrombosis, Reserach Laboratories, Fondazione di Ricerca e Cura \"Giovanni Paolo II\", Università Cattolica, Campobasso, Italy Shardna Life Sciences, Cagliari, Italy Reserach Laboratories, Fondazione di Ricerca e Cura \"Giovanni Paolo II\", Università Cattolica, Campobasso, Italy Department of Internal Medicine, IRCCS Foundation Policlinico S. Matteo, University of Pavia, Pavia, Italy (literal)
Titolo
  • Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data. (literal)
Abstract
  • Although several studies demonstrated that platelet count is higher in women, decreases with age, and is influenced by genetic background, most clinical laboratories still use the reference interval 150-400×10(9) platelets/L for all subjects. The present study was to identify age- and sex-specific reference intervals for platelet count. METHODS: We analysed electronic records of subjects enrolled in three population-based studies that investigated inhabitants of seven Italian areas including six geographic isolates. After exclusion of patients with malignancies, liver diseases, or inherited thrombocytopenias, which could affect platelet count, reference intervals were estimated from 40,987 subjects with the non parametric method computing the 2.5° and 97.5° percentiles. RESULTS: Platelet count was similar in men and women until the age of 14, but subsequently women had steadily more platelets than men. The number of platelets decreases quickly in childhood, stabilizes in adulthood, and further decreases in oldness. The final result of this phenomenon is that platelet count in old age was reduced by 35% in men and by 25% in women compared with early infancy. Based on these findings, we estimated reference intervals for platelet count ×10(9)/L in children (176-452), adult men (141-362), adult women (156-405), old men (122-350) and, old women (140-379). Moreover, we calculated an \"extended\" reference interval that takes into account the differences in platelet count observed in different geographic areas. CONCLUSIONS: The age-, sex-, and origin-related variability of platelet count is very wide, and the patient-adapted reference intervals we propose change the thresholds for diagnosing both thrombocytopenia and thrombocytosis in Italy. (literal)
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