Geometric and dosimetric approach to determine probability of late cardiac mortality in left tangential breast irradiation: comparison between wedged beams and field-in-field technique. (Articolo in rivista)

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  • Geometric and dosimetric approach to determine probability of late cardiac mortality in left tangential breast irradiation: comparison between wedged beams and field-in-field technique. (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.ijrobp.2010.12.021 (literal)
Alternative label
  • Pili, G (Pili, Giorgio)[ 1 ] ; Grimaldi, L (Grimaldi, Luca)[ 1 ] ; Fidanza, C (Fidanza, Christian)[ 1 ] ; Florio, ET (Florio, Elena T.)[ 1 ] ; Petruzzelli, MF (Petruzzelli, Maria F.)[ 2 ] ; D'Errico, MP (D'Errico, Maria P.)[ 3 ] ; De Tommaso, C (De Tommaso, Cristina)[ 2 ] ; Tramacere, F (Tramacere, Francesco)[ 2 ] ; Musaio, F (Musaio, Francesca)[ 1 ] ; Castagna, R (Castagna, Roberta)[ 2 ] ; Francavilla, MC (Francavilla, Maria C.)[ 2 ] ; Gianicolo, EAL (Gianicolo, Emilio A. L.)[ 4 ] ; Portaluri, M (Portaluri, Maurizio)[ 2,4 ] (2011)
    Geometric and dosimetric approach to determine probability of late cardiac mortality in left tangential breast irradiation: comparison between wedged beams and field-in-field technique.
    in International journal of radiation oncology, biology, physics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pili, G (Pili, Giorgio)[ 1 ] ; Grimaldi, L (Grimaldi, Luca)[ 1 ] ; Fidanza, C (Fidanza, Christian)[ 1 ] ; Florio, ET (Florio, Elena T.)[ 1 ] ; Petruzzelli, MF (Petruzzelli, Maria F.)[ 2 ] ; D'Errico, MP (D'Errico, Maria P.)[ 3 ] ; De Tommaso, C (De Tommaso, Cristina)[ 2 ] ; Tramacere, F (Tramacere, Francesco)[ 2 ] ; Musaio, F (Musaio, Francesca)[ 1 ] ; Castagna, R (Castagna, Roberta)[ 2 ] ; Francavilla, MC (Francavilla, Maria C.)[ 2 ] ; Gianicolo, EAL (Gianicolo, Emilio A. L.)[ 4 ] ; Portaluri, M (Portaluri, Maurizio)[ 2,4 ] (literal)
Pagina inizio
  • 894 (literal)
Pagina fine
  • 900 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 81 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 3 (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • [ 1 ] A Perrino Hosp, Dept Med Phys, Brindisi, Italy [ 2 ] A Perrino Hosp, Dept Radiat Oncol, Brindisi, Italy [ 3 ] A Perrino Hosp, Dept Lab Med, Brindisi, Italy [ 4 ] CNR, Inst Clin Physiol, Pisa, Italy (literal)
Titolo
  • Geometric and dosimetric approach to determine probability of late cardiac mortality in left tangential breast irradiation: comparison between wedged beams and field-in-field technique. (literal)
Abstract
  • Purpose: To evaluate the probability of late cardiac mortality resulting from left breast irradiation planned with tangential fields and to compare this probability between the wedged beam and field-in-field (FIF) techniques and to investigate whether some geometric/dosimetric indicators can be determined to estimate the cardiac mortality probability before treatment begins. Methods and Materials: For 30 patients, differential dose volume histograms were calculated for the wedged beam and FIF plans, and the corresponding cardiac mortality probabilities were determined using the relative seriality model. As a comparative index of the dose distribution uniformity, the planning target volume (PTV) percentages involved in 97-103% of prescribed dose were determined for the two techniques. Three geometric parameters were measured for each patient: the maximal length, indicates how much the heart contours were displaced toward the PTV, the angle subtended at the center of the computed tomography slice by the PTV contour, and the thorax width/thickness ratio. Results: Evaluating the differential dose volume histograms showed that the gain in uniformity between the two techniques was about 1.5. With the FIF technique, the mean dose sparing for the heart, the left anterior descending coronary artery, and the lung was 15% (2.5 Gy vs. 2.2 Gy), 21% (11.3 Gy vs. 9.0 Gy), and 42% (8.0 Gy vs. 4.6 Gy) respectively, compared with the wedged beam technique. Also, the cardiac mortality probability decreased by 40% (from 0.9% to 0.5%). Three geometric parameters, the maximal length, angle subtended at the center of the computed tomography slice by the PTV contour, and thorax width/thickness ratio, were the determining factors (p = .06 for FIF, and p = .10 for wedged beam) for evaluating the cardiac mortality probability. Conclusion: The FIF technique seemed to yield a lower cardiac mortality probability than the conventional wedged beam technique. However, although our study demonstrated that FIF technique improved the dose coverage of the PTV, the restricted number of patients enrolled and the short follow-up did not allow us to evaluate and compare the breast cancer survival rates of the patients (literal)
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