Pathophysiology of prediabetes (Articolo in rivista)

Type
Label
  • Pathophysiology of prediabetes (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.mcna.2010.11.005 (literal)
Alternative label
  • 2)Gastaldelli, Amalia; 1)Ferrannini, Ele; 1)IOZZO, PATRICIA (2011)
    Pathophysiology of prediabetes
    in The Medical clinics of North America
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • 2)Gastaldelli, Amalia; 1)Ferrannini, Ele; 1)IOZZO, PATRICIA (literal)
Pagina inizio
  • 327 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 95 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • [ 1 ] Univ Pisa, Sch Med, Dept Internal Med, I-56100 Pisa, Italy [ 2 ] CNR, Inst Clin Physiol, I-56100 Pisa, Italy (literal)
Titolo
  • Pathophysiology of prediabetes (literal)
Abstract
  • Prediabetes encompasses conventional diagnostic categories of impaired fasting glucose and impaired glucose tolerance but is a band of glucose concentrations and a temporal phase over a continuum extending from conventional normal glucose tolerance to overt type 2 diabetes. Insulin resistance and defective glucose sensing at the beta-cell are the central pathophysiologic determinants that together cause hyperglycemia. Regardless of the cellular origin of insulin resistance, excessive tissue fat utilization is a consistent metabolic mechanism. Although genetic influences affect beta-cell function, becoming overweight is the main acquired challenge to insulin action. The phenotype of prediabetes includes dyslipidemia and higher arterial blood pressure. (literal)
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Autore CNR

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