Protective role of adiponectin on endothelial dysfunction induced by AGEs: A clinical and experimental approach (Articolo in rivista)

Type
Label
  • Protective role of adiponectin on endothelial dysfunction induced by AGEs: A clinical and experimental approach (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.mvr.2011.03.003 (literal)
Alternative label
  • Gastaldelli, Amalia; Basta, Giuseppina; Del Turco, Serena; Navarra, Teresa (2011)
    Protective role of adiponectin on endothelial dysfunction induced by AGEs: A clinical and experimental approach
    in Microvascular research (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Gastaldelli, Amalia; Basta, Giuseppina; Del Turco, Serena; Navarra, Teresa (literal)
Pagina inizio
  • 73 (literal)
Pagina fine
  • 76 (literal)
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  • 82 (literal)
Rivista
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  • 4 (literal)
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  • 1 (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • CNR, Inst Clin Physiol, San Cataldo Res Area, I-56124 Pisa, Italy (literal)
Titolo
  • Protective role of adiponectin on endothelial dysfunction induced by AGEs: A clinical and experimental approach (literal)
Abstract
  • Objective: Obesity is characterized by low levels of adiponectin, an adipocytes derived hormone, and by an inflammatory component. Endothelial dysfunction is often found in overweight/obesity, diabetes, and atherosclerosis. Advanced glycation end products (AGES) induce endothelial dysfunction and are linked to diabetes and increased atherogenicity and inflammation. The aim of the study was to investigate the possible link between adiponectin and N(epsilon)-(carboxymethyl) lysine (CML), the predominant adduct of circulating AGES in overweight patients, and, in an in vitro model, to test the hypothesis that adiponectin acts as modulator of endothelial dysfunction, induced by AGEs. Results: In 108 overweight patients, plasma levels of CML correlated inversely with adiponectin levels. Pre-incubation of human vein endothelial cells (HUVECs) with physiological concentrations of adiponectin, followed by stimulation with AGEs, reduced vascular adhesion molecule-1 (VCAM-1) and E-selectin expression, as assessed by surface enzyme immunoassay. Conclusions: Taken together, these findings demonstrate an inverse correlation between CML and adiponectin levels in overweight patients and a protective role of adiponectin on endothelial dysfunction induced by ACEs, suggesting its key role in the treatment of the vascular complications of obesity/metabolic syndrome (literal)
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