Evaluation of gene, protein and neurotrophin expression in the brain of mice exposed to space environment for 91 days (Articolo in rivista)

Type
Label
  • Evaluation of gene, protein and neurotrophin expression in the brain of mice exposed to space environment for 91 days (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1371/journal.pone.0040112 (literal)
Alternative label
  • Santucci Daniela1; Kawano Fuminori 2; Ohira Takashi3; Terada Masahiro4; Nakai Naoya2; Francia Nadia1; Alleva Enrico1; Aloe Luigi5; Ochiai Toshimasa6; Cancedda Ranieri7; Goto Katsumasa8; Ohira Yoshinobu2 (2012)
    Evaluation of gene, protein and neurotrophin expression in the brain of mice exposed to space environment for 91 days
    in PloS one
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Santucci Daniela1; Kawano Fuminori 2; Ohira Takashi3; Terada Masahiro4; Nakai Naoya2; Francia Nadia1; Alleva Enrico1; Aloe Luigi5; Ochiai Toshimasa6; Cancedda Ranieri7; Goto Katsumasa8; Ohira Yoshinobu2 (literal)
Pagina fine
  • e40112 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Behavioural Neuroscience Section, Cellular Biology and Neuroscience Department, Istituto Superiore di Sanità, Rome, Italy. 2 Graduate School of Medicine, Osaka University, Osaka, Japan. 3 Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan. 4 Japan Aerospace Exploration Agency, Ibaraki, Japan 5 Luigi Aloe Institute of Neurobiology and Molecular Medicine, CNR, European Brain Research Institute, Rome, Italy (*). 6 Mitsubishi Heavy Industries, Hyogo, Japan. 7 DOBIG, University of Genova, Genova, Italy. 8 Graduate School of Health Sciences, Toyohashi SOZO University, Aichi, Japan. (*) Confluito in IBCN - Provvedimento del Presidente del CNR n. 116 del 21/12/2010 prot. n. 0091899 (literal)
Titolo
  • Evaluation of gene, protein and neurotrophin expression in the brain of mice exposed to space environment for 91 days (literal)
Abstract
  • Effects of 3-month exposure to microgravity environment on the expression of genes and proteins in mouse brain were studied. Moreover, responses of neurobiological parameters, nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), were also evaluated in the cerebellum, hippocampus, cortex, and adrenal glands. Spaceflight-related changes in gene and protein expression were observed. Biological processes of the up-regulated genes were related to the immune response, metabolic process, and/or inflammatory response. Changes of cellular components involving in microsome and vesicular fraction were also noted. Molecular function categories were related to various enzyme activities. The biological processes in the down-regulated genes were related to various metabolic and catabolic processes. Cellular components were related to cytoplasm and mitochondrion. The down-regulated molecular functions were related to catalytic and oxidoreductase activities. Up-regulation of 28 proteins was seen following spaceflight vs. those in ground control. These proteins were related to mitochondrial metabolism, synthesis and hydrolysis of ATP, calcium/calmodulin metabolism, nervous system, and transport of proteins and/or amino acids. Down-regulated proteins were related to mitochondrial metabolism. Expression of NGF in hippocampus, cortex, and adrenal gland of wild type animal tended to decrease following spaceflight. As for pleiotrophin transgenic mice, spaceflight-related reduction of NGF occured only in adrenal gland. Consistent trends between various portions of brain and adrenal gland were not observed in the responses of BDNF to spaceflight. Although exposure to real microgravity influenced the expression of a number of genes and proteins in the brain that have been shown to be involved in a wide spectrum of biological function, it is still unclear how the functional properties of brain were influenced by 3-month exposure to microgravity. (literal)
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