Simultaneous determination of plasma levels and cardiac expression of CNP in end-stage heart failure patients undergoing left ventricular assist devices (Abstract in rivista)

Type

• Prodotto della ricerca (Classe)
• Abstract in rivista (Classe)

Label

• Simultaneous determination of plasma levels and cardiac expression of CNP in end-stage heart failure patients undergoing left ventricular assist devices (Abstract in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• M. Cabiati, R. Caruso, C. Caselli, C. Baroni, T. Prescimone, M. Frigerio, D. Giannessi, S. Del Ry, O. Parodi (2011)
  Simultaneous determination of plasma levels and cardiac expression of CNP in end-stage heart failure patients undergoing left ventricular assist devices
  
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• M. Cabiati, R. Caruso, C. Caselli, C. Baroni, T. Prescimone, M. Frigerio, D. Giannessi, S. Del Ry, O. Parodi (literal)

Pagina inizio

• 913 (literal)

Pagina fine

• 913 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• ID_PUMA: cnr.ifc/2011-A7-003 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://eurheartj.oxfordjournals.org/content/32/suppl_1.toc (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 32 (literal)

Rivista

• European heart journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• S1 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR Institute of Clinical Physiology and Gabriele Monasterio Foundation, Pisa, Italy ; CNR Clinical Physiology Institute, Milan, Italy, Milan, Italy ; Siena University, Pisa, Italy (literal)

Titolo

• Simultaneous determination of plasma levels and cardiac expression of CNP in end-stage heart failure patients undergoing left ventricular assist devices (literal)

Abstract

• Purpose: Left ventricular assist devices (LVAD) implantation represents an alternative to heart transplantation, leading to a modification of neurohormonal profile and contributing to myocardial recovery. Few data are available about the involvement of C-type natriuretic peptide (CNP), and its specific receptor (NPR-B) during LVAD. The aim of the study was to evaluate the role of CNP in deteriorating HF patients undergoing LVAD implant, by the simultaneous determination of plasma levels and cardiac expression of both CNP and NPR-B. Methods: Seventeen LVAD patients (NYHA III- IV; LVEF<20%) were studied: 10 survived up to 1 month after LVAD (S) and 7 died of multiple-organ failure within 2 weeks (NS). Blood samples were obtained at admission (T1), at 4, 24, 72 hrs and 1, 2, 4 weeks (T2-T7) after LVAD implant. Cardiac biopsies were collected from left ventricle at time of heart transplantation. As controls, transplanted patients were enrolled. NT-proCNP plasma levels were measured by a direct immunometric assay. A RT-PCR analysis were performed to evaluate gene cardiac expression. Results: In S patients, after an initial increase of CNP levels, a reduction to basal levels was found 4 weeks post-LVAD, while in NS patients NT-proCNP sustained higher with a peak at 24 hrs and 72 hrs. A co-localization for CNP and NPR-B was showed in cardiac tissue of both LVAD and transplanted patients, although no significant difference in their mRNA expression was observed. (literal)

Prodotto di

• Meccanismi molecolari e biologici (ME.P05.018.002) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• OBERDAN PARODI (Persona)
• DANIELA GIANNESSI (Unità di personale interno)
• RAFFAELE CARUSO (Unità di personale interno)
• TOMMASO PRESCIMONE (Unità di personale esterno)
• CHIARA CASELLI (Unità di personale interno)
• SILVIA DEL RY (Unità di personale interno)
• Manuela Cabiati (Persona)

Incoming links:

Autore CNR di

• DANIELA GIANNESSI (Unità di personale interno)
• OBERDAN PARODI (Persona)
• SILVIA DEL RY (Unità di personale interno)
• RAFFAELE CARUSO (Unità di personale interno)
• CHIARA CASELLI (Unità di personale interno)
• Manuela Cabiati (Persona)
• TOMMASO PRESCIMONE (Unità di personale esterno)

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)
• Meccanismi molecolari e biologici (ME.P05.018.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European heart journal (Rivista)