Comparative effect of apheresis vs Atorvastatin/apheresis on markers of inflammation in patients with familial hypercholesterolemia (Abstract/Comunicazione in atti di convegno)

Type
Label
  • Comparative effect of apheresis vs Atorvastatin/apheresis on markers of inflammation in patients with familial hypercholesterolemia (Abstract/Comunicazione in atti di convegno) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/S1567-5688(11)70113-1 (literal)
Alternative label
  • M. Puntoni, F. Sbrana, F. Bigazzi, F. Minichilli, T. Sampietro (2011)
    Comparative effect of apheresis vs Atorvastatin/apheresis on markers of inflammation in patients with familial hypercholesterolemia
    in 79. EAS congress, Gothenburg, Sweden, 26 - 29 June 2011
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • M. Puntoni, F. Sbrana, F. Bigazzi, F. Minichilli, T. Sampietro (literal)
Pagina inizio
  • 26 (literal)
Pagina fine
  • 27 (literal)
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  • PUMA_ID: cnr.ifc/2011-A6-014 (literal)
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  • http://www.sciencedirect.com/science/article/pii/S1567568811701131# (literal)
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  • 12 (literal)
Rivista
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  • 1 (literal)
Note
  • Abstract (literal)
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  • Institute of Clinical Physiology - CNR ; Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Pisa, Italy (literal)
Titolo
  • Comparative effect of apheresis vs Atorvastatin/apheresis on markers of inflammation in patients with familial hypercholesterolemia (literal)
Abstract
  • Objective: Patients with Familial Hypercholesterolemia (FH) have increased cardiovascular events. Clinical trials have demonstrated that lowering circulating lipid levels by LDL-apheresis has beneficial effects on prognosis. However, whether apheresis vascular effects in FH are related to modulation of pro- and anti-inflammatory cytokines, and whether the combination of apheresis with atorvastatin is able to enhance the putative anti-inflammatory effect of apheresis remains unknown. We examined, in a intra-patient study, the effect of atorvastatin/apheresis vs. apheresis alone on the releasing of circulating pro- and anti-inflammatory markers. Methods: 9 heterozygous patients (56+11 years) with FH (mean cholesterol 385+42 mg/dL) were treated with apheresis alone and afterwards with apheresis plus atorvastatin 40 mg/d. Lipid profiles, serum C-reactive protein, CK, GOT, GGT, the antiinflammatory markers IL-4 and IL-10 and the pro-inflammatory markers INFg and IL-6 were determined before and at 2, 4, 6 and 8 days after apheresis and atorvastatin/apheresis. Results: Treatment with atorvastatin/apheresis significantly reduced lipid profile more than LDL-apheresis alone at each scheduled time. When compared to apheresis alone, combined treatment statistically decreased cholesterol by more than 25-35% at all times and relatively increased IL-4 concentration. The levels of cholesterol in atorvastatin/apheresis patients were inversely correlated with those of IL-4 and IL-10 and positively correlated with IFNg. Conclusion: The combination of atorvastatin with LDL-apheresis decreased serum cholesterol levels more than apheresis alone. Apheresis had an anti-inflammatory effect and the effect of the drug reducing cholesterol levels affects the balance between proand anti-inflammatory cytokines in favor of anti-inflammation contribute. (literal)
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