http://www.cnr.it/ontology/cnr/individuo/prodotto/ID202669

Deferasirox, Deferiprone and Desferrioxamine Treatment in Thalassemia Major Patients: Cardiac Iron and Function Comparison Determined by Quantitative Magnetic Resonance Imaging (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Deferasirox, Deferiprone and Desferrioxamine Treatment in Thalassemia Major Patients: Cardiac Iron and Function Comparison Determined by Quantitative Magnetic Resonance Imaging (Articolo in rivista) (literal)

Anno

2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.3324/haematol.2009.019042 (literal)

Alternative label

Pepe, Alessia [ 1 ]; Meloni, Antonella [ 1 ]; Capra, Marcello [ 3 ]; Cianciulli, Paolo [ 4 ]; Prossomariti, Luciano [ 5 ]; Malaventura, Cristina [ 6 ]; Putti, Maria Caterina [ 7,9 ]; Lippi, Alma [ 8 ]; Romeo, Maria Antonietta; Bisconte, Maria Grazia [ 10 ]; Filosa, Aldo [ 11 ]; Caruso, Vincenzo [ 12 ]; Quarta, Antonella [ 13 ]; Pitrolo, Lorella [ 14 ]; Missere, Massimiliano[ 15 ] ; Midiri, Massimo [ 16 ] ; Rossi, Giuseppe [ 2 ]; Positano, Vincenzo [ 1 ]; Lombardi, Massimo [ 1 ]; Maggio, Aurelio [ 17 ] (2011)
Deferasirox, Deferiprone and Desferrioxamine Treatment in Thalassemia Major Patients: Cardiac Iron and Function Comparison Determined by Quantitative Magnetic Resonance Imaging
in Haematologica (Roma)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Pepe, Alessia [ 1 ]; Meloni, Antonella [ 1 ]; Capra, Marcello [ 3 ]; Cianciulli, Paolo [ 4 ]; Prossomariti, Luciano [ 5 ]; Malaventura, Cristina [ 6 ]; Putti, Maria Caterina [ 7,9 ]; Lippi, Alma [ 8 ]; Romeo, Maria Antonietta; Bisconte, Maria Grazia [ 10 ]; Filosa, Aldo [ 11 ]; Caruso, Vincenzo [ 12 ]; Quarta, Antonella [ 13 ]; Pitrolo, Lorella [ 14 ]; Missere, Massimiliano[ 15 ] ; Midiri, Massimo [ 16 ] ; Rossi, Giuseppe [ 2 ]; Positano, Vincenzo [ 1 ]; Lombardi, Massimo [ 1 ]; Maggio, Aurelio [ 17 ] (literal)

Pagina inizio

41 (literal)

Pagina fine

47 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

ID_PUMA: cnr.ifc/2011-A0-157 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

96 (literal)

Rivista

Haematologica (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

1 (literal)

Note

ISI Web of Science (WOS) (literal)
Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

[ 1 ] CNR Reg Toscana, Fdn G Monasterio, Magnet Resonance Imaging Unit, I-56124 Pisa, Italy;[ 2 ] CNR, Inst Clin Physiol, Epidemiol & Biostat Unit, I-56100 Pisa, Italy;[ 3 ] G Di Cristina Hosp, ARNAS, Palermo, Italy;[ 4 ] St Eugenio Hosp, Ctr Talassemie, Rome, Italy; [ 5 ] Cardarelli Hosp, Ctr Cura Microcitemie, Naples, Italy, [ 6 ] Univ Ferrara, Dept Pediat, I-44100 Ferrara, Italy; [ 7 ] Univ Padua, Dept Pediat, Padua, Italy, [ 8 ] Meyer Hosp, Ctr Talassemie & Emoglobinopatie, Florence, Italy; [ 9 ] Univ Catania, Dept Pediat, Catania, Italy, [ 10 ] Presidio Osp Annunziata, Ctr Microcitemia UO Ematol, Cosenza, Italy; [ 11 ] Cardarelli Hosp, UOC Pediat, DH Thalassemia, Naples, Italy; [ 12 ] Ctr Microcitemia Garibaldi Hosp, Catania, Italy; [ 13 ] Ematol A Perrino Hosp, Brindisi, Italy; [ 14 ] Villa Sofia CTO Hosp, Palermo, Italy, [ 15 ] John Paul II Catholic Univ, Dept Radiol, Campobasso, Italy; [16 ] Univ Palermo, Dept Radiol, Palermo, Italy; [ 17 ] V Cervello Hosp, Palermo, Italy (literal)

Titolo

Deferasirox, Deferiprone and Desferrioxamine Treatment in Thalassemia Major Patients: Cardiac Iron and Function Comparison Determined by Quantitative Magnetic Resonance Imaging (literal)

Abstract

Background Oral deferiprone was suggested to be more effective than subcutaneous desferrioxamine for removing heart iron. Oral once-daily chelator deferasirox has recently been made commercially available but its long-term efficacy on cardiac iron and function has not yet been established. Our study aimed to compare the effectiveness of deferasirox, deferiprone and desferrioxamine on myocardial and liver iron concentrations and bi-ventricular function in thalassemia major patients by means of quantitative magnetic resonance imaging. Design and Methods From the first 550 thalassemia subjects enrolled in the Myocardial Iron Overload in Thalassemia network, we retrospectively selected thalassemia major patients who had been receiving one chelator alone for longer than one year. We identified three groups of patients: 24 treated with deferasirox, 42 treated with deferiprone and 89 treated with desferrioxamine. Myocardial iron concentrations were measured by T2* multislice multiecho technique. Biventricular function parameters were quantitatively evaluated by cine images. Liver iron concentrations were measured by T2* multiecho technique. Results The global heart T2* value was significantly higher in the deferiprone (34±11ms) than in the deferasirox (21±12 ms) and the desferrioxamine groups (27±11 ms) (P=0.0001). We found higher left ventricular ejection fractions in the deferiprone and the desferrioxamine versus the deferasirox group (P=0.010). Liver iron concentration, measured as T2* signal, was significantly lower in the desferrioxamine versus the deferiprone and the deferasirox group (P=0.004). Conclusions The cohort of patients treated with oral deferiprone showed less myocardial iron burden and better global systolic ventricular function compared to the patients treated with oral deferasirox or subcutaneous desferrioxamine. (literal)

Prodotto di