http://www.cnr.it/ontology/cnr/individuo/prodotto/ID202631
Vitamin D status may contribute to serum insulin-like growth factor I concentrations in healthy subjects (Articolo in rivista)
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- Vitamin D status may contribute to serum insulin-like growth factor I concentrations in healthy subjects (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
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- Alternative label
1 Bogazzi, F. ; 2 Rossi, G. ; 1 Lombardi, M. ; 1 Tomisti, L. ; 1 Sardella, C. ; 1 Manetti, L. ; 2 Curzio, O. ; 1 Marcocci, C. ; 1 Grasso, L. ; 3 Gasperi, M. ; 1 Martino, E. (2011)
Vitamin D status may contribute to serum insulin-like growth factor I concentrations in healthy subjects
in Journal of endocrinological investigation (Testo stamp.)
(literal)
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- 1 Bogazzi, F. ; 2 Rossi, G. ; 1 Lombardi, M. ; 1 Tomisti, L. ; 1 Sardella, C. ; 1 Manetti, L. ; 2 Curzio, O. ; 1 Marcocci, C. ; 1 Grasso, L. ; 3 Gasperi, M. ; 1 Martino, E. (literal)
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- 1Department of Endocrinology and Metabolism, University of Pisa ; ²Epidemiology and Biostatistics Unit, Institute of Clinical Physiology, National Research Council, Pisa ; 3Chair of Endocrinology, University of Molise, Campobasso, Italy (literal)
- Titolo
- Vitamin D status may contribute to serum insulin-like growth factor I concentrations in healthy subjects (literal)
- Abstract
- Objective: The aim of the study was to evaluate whether vitamin D[25-(OH) D(3)] status affects serum IGF-I concentrations in healthy subjects. Design and patients: Two hundred and forty-one consecutive healthy subjects were included in the present study. Measurements: Serum IGF-I and 25-(OH) D(3) concentrations. Results: As expected, serum IGF-I concentrations progressively decreased with age (r=-0.55, p<0.0001); on the contrary, gender was not related to serum IGF-I levels. A positive relationship was identified between serum 25-(OH) D(3) and IGF-I concentrations (r=0.33, p<0.0001); the 25-(OH) D(3)-dependent changes of serum IGF-I concentrations were observed also when subjects were divided on the basis of vitamin D deficiency; in fact, those with severe 25-(OH) D(3) deficiency (<20 ng/ml) had lower (185 +/- 83 mu g/l) IGF-I values than those with mild-to absent 25-(OH) D(3) deficit (225 83 mu g/l, p=0.0004). Conclusions: 25-(OH) D(3) status may contribute to determine serum IGF-I levels in healthy population (literal)
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