http://www.cnr.it/ontology/cnr/individuo/prodotto/ID202614
Elevated soluble receptor for advanced glycation end product levels in patients with acute coronary syndrome and positive cardiac troponin I (Articolo in rivista)
- Type
- Label
- Elevated soluble receptor for advanced glycation end product levels in patients with acute coronary syndrome and positive cardiac troponin I (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1097/MCA.0b013e32834c751f (literal)
- Alternative label
Mercuri, Antonella (1); Basta, Giuseppina (1); Battaglia, Debora (2); Mazzone, Annamaria (3); BERTI, SERGIO (3); Del Turco, Serena (1); Navarra, Teresa (1); Marchi, Federica (3) (2011)
Elevated soluble receptor for advanced glycation end product levels in patients with acute coronary syndrome and positive cardiac troponin I
in Coronary artery disease
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Mercuri, Antonella (1); Basta, Giuseppina (1); Battaglia, Debora (2); Mazzone, Annamaria (3); BERTI, SERGIO (3); Del Turco, Serena (1); Navarra, Teresa (1); Marchi, Federica (3) (literal)
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- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- (1) CNR-IFC, Pisa; (2) Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy; (3) Fondazione G. Monasterio CNR-Regione Toscana, Massa, Italy (literal)
- Titolo
- Elevated soluble receptor for advanced glycation end product levels in patients with acute coronary syndrome and positive cardiac troponin I (literal)
- Abstract
- Objectives High levels of soluble receptor for advanced glycation end products (sRAGE) have been shown to have an atheroprotective role; however, no data are available on this molecule in acute coronary syndromes (ACS). We evaluated sRAGE levels in patients with non-ST segment elevation ACS (NSTE-ACS) or with chronic stable angina.
Methods We studied 265 patients, 190 of whom had NSTE-ACS and 75 had chronic stable angina.
Results Plasma sRAGE values were comparable in the two groups (P = 0.19). However, in the patients with NSTE-ACS, sRAGE levels were significantly higher in patients with cardiac troponin-I (cTnI) of more than or equal to 0.04 mu g/l compared with those with cTnI of less than 0.04 mu g/l [ 758 (493-1536) pg/ml vs. 454 (167-899) pg/ml; P = 0.0037]. A significant correlation (r = 0.323, P = 0.0045) was found between sRAGE and cTnI levels in patients with NSTE-ACS.
Conclusion Plasma sRAGE levels are elevated in patients with NSTE-ACS with positive cTnI, suggesting that they could be related to myocardial cell damage (literal)
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