http://www.cnr.it/ontology/cnr/individuo/prodotto/ID202612
ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries (Articolo in rivista)
- Type
- Label
- ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1109/TITB.2011.2168418 (literal)
- Alternative label
Filipovic, N (2); Rosic, M. (2); Tanaskovic, I. (2); Milosevic, Z. (3); Nikolic, D. (3); Zdravkovic, N. (2); Peulic, A. (4); Kojic, M.R. (5) Fotiadis, D.I. (6); Parodi, O. (1); (2012)
ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries
in IEEE transactions on information technology in biomedicine
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Filipovic, N (2); Rosic, M. (2); Tanaskovic, I. (2); Milosevic, Z. (3); Nikolic, D. (3); Zdravkovic, N. (2); Peulic, A. (4); Kojic, M.R. (5) Fotiadis, D.I. (6); Parodi, O. (1); (literal)
- Pagina inizio
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- ID-PUMA: cnr.ifc/2011-A0-149. Manuscript received April 15, 2011; revised July 26, 2011; accepted August 30, 2011. Date of publication September 19, 2011; date of current version March 7, 2012 (literal)
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- Note
- ISI Web of Science (WOS) (literal)
- Scopu (literal)
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- (1) CNR-IFC, Pisa; (2) University of Kragujevac, Serbia; (3) Bioengineering Research and Development Center, Kragujevac, Serbia; (4) Technical Faculty Cacak, University of Kragujevac Cacak, Serbia; (5) Methodist Hospital System, Houston, TX 77030 USA; (6) University of Ioannina, 45110 Ioannina, Greece (literal)
- Titolo
- ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries (literal)
- Abstract
- Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented. (literal)
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