http://www.cnr.it/ontology/cnr/individuo/prodotto/ID202518

The Metabolic Syndrome and Risk of Prostate Cancer in Italy (Articolo in rivista)

Type

Label

The Metabolic Syndrome and Risk of Prostate Cancer in Italy (Articolo in rivista) (literal)

Anno

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

Alternative label

Pelucchi, C. (3); Serraino, A. (1); Negri, A. (3); Montella, A. (4); Dellanoce, Cinzia (2); Talamini, Renato (1); La Vecchia, C. (3) (2011)
The Metabolic Syndrome and Risk of Prostate Cancer in Italy
in Annals of epidemiology
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Pelucchi, C. (3); Serraino, A. (1); Negri, A. (3); Montella, A. (4); Dellanoce, Cinzia (2); Talamini, Renato (1); La Vecchia, C. (3) (literal)

Pagina inizio

Pagina fine

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Rivista

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Note

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(1) UOC Epidemiology and Biostatistic - IRCCS Centro di riferimento oncologico Aviano (PN); (2) CNR-IFC, Milano; (3) C.E.R.P. (Center for the Evaluation and Research on Pain) - Istituto di Ricerche Farmacologiche Mario Negri; (4) Istituto Nazionale Tumori, Napoli (Italy) (literal)

Titolo

Abstract

To provide information on the role of the metabolic syndrome on prostate cancer risk.We examined data from a multicentric Italian case-control study. Cases were 1294 patients with incident, histologically confirmed prostate cancer. Controls were 1451 men hospitalized with acute, non-neoplastic conditions. All subjects were younger than 75 years. The metabolic syndrome was defined according to selected indicators of abdominal obesity, hypercholesterolemia, hypertension, and diabetes. We computed multivariate odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression.Considering separate components of the metabolic syndrome, the ORs were 0.98 (95% CI, 0.72-1.34) for diabetes, 1.14 (95% CI, 0.96-1.36) for hypertension, 1.54 (95% CI, 1.26-1.89) for hypercholesterolemia, and 1.02 (95% CI, 0.86-1.21) for abdominal obesity. The OR of prostate cancer was 1.66 (95% CI, 1.22-2.28) in men with metabolic syndrome compared with those without. We found ORs of 1.02 (95% CI, 0.83-1.26) for men with one component of the metabolic syndrome, 1.12 (95% CI, 0.89- 1.42) for two, 1.65 (95% CI, 1.15-2.36) for three, and 3.99 (95% CI, 1.03-15.4) for four compared with no components.The metabolic syndrome was associated with the risk of prostate cancer in this population. (literal)

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