Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/j.1478-3231.2011.02462.x (literal)

Alternative label

• Gianluca Svegliati-Baroni 1, Stefania Saccomanno 1, Chiara Rychlicki 1, Laura Agostinelli 1, Samuele De Minicis 1, Cinzia Candelaresi 1, Graziella Faraci 1, Deborah Pacetti 2, Marco Vivarelli 3, Daniele Nicolini 3, Paolo Garelli 3, Alessandro Casini 4, Melania Manco 5, Geltrude Mingrone 6, Andrea Risaliti 3, Giuseppe N. Frega 2, Antonio Benedetti 1 and Amalia Gastaldelli 7 (2011)
  Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis
  in Liver international (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Gianluca Svegliati-Baroni 1, Stefania Saccomanno 1, Chiara Rychlicki 1, Laura Agostinelli 1, Samuele De Minicis 1, Cinzia Candelaresi 1, Graziella Faraci 1, Deborah Pacetti 2, Marco Vivarelli 3, Daniele Nicolini 3, Paolo Garelli 3, Alessandro Casini 4, Melania Manco 5, Geltrude Mingrone 6, Andrea Risaliti 3, Giuseppe N. Frega 2, Antonio Benedetti 1 and Amalia Gastaldelli 7 (literal)

Pagina inizio

• 1285 (literal)

Pagina fine

• 1297 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• ID_PUMA: cnr.ifc/2011-A0-135 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 31 (literal)

Rivista

• Liver international (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 9 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy; 2 Department of Food Science, Polytechnic University of Marche, Ancona, Italy; 3 Transplant Center, Polytechnic University of Marche, Ancona, Italy; 4 Nutrition Center and GI Unit, University of Florence, Florence, Italy; 5 Pediatric Hospital 'Bambino Gesu`, IRCCS, Rome, Italy; 6 Department of Internal Medicine, Catholic University, Rome, Italy; 7 Institute of Clinical Physiology, National Research Council (IFC-CNR), Pisa, Italy (literal)

Titolo

• Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis (literal)

Abstract

• Background/Aims: High-fat dietary intake and low physical activity lead to insulin resistance, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Recent studies have shown an effect of glucagon-like peptide-1 (GLP-1) on hepatic glucose metabolism, although GLP-1 receptors (GLP-1r) have not been found in human livers. The aim of this study was to investigate the presence of hepatic GLP-1r and the effect of exenatide, a GLP-1 analogue, on hepatic signalling. Methods: The expression of GLP-1r was evaluated in human liver biopsies and in the livers of high-fat diet-treated rats. The effect of exenatide (100 nM) was evaluated in hepatic cells of rats fed 3 months with the high-fat diet. Results: GLP-1r is expressed in human hepatocytes, although reduced in patients with NASH. Similarly, in rats with NASH resulted from 3 months of the high-fat diet, we found a decreased expression of GLP-1r and peroxisome proliferator-activated receptor gamma (PPARgamma), and reduced peroxisome proliferator-activated receptor alpha (PPARalpha) activity. Incubation of hepatocytes with exenatide increased PPARgamma expression, which also exerted an insulin-sensitizing action by reducing JNK phosphorylation. Moreover, exenatide increased protein kinase A (PKA) activity, Akt and AMPK phosphorylation and determined a PKA-dependent increase of PPARalpha activity. Conclusions: GLP-1 has a direct effect on hepatocytes, by activating genes involved in fatty acid beta-oxidation and insulin sensitivity. GLP-1 analogues could be a promising treatment approach to improve hepatic insulin resistance in patients with NAFLD/NASH. (literal)

Prodotto di

• Meccanismi molecolari e biologici (ME.P05.018.002) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• AMALIA GASTALDELLI (Persona)

Insieme di parole chiave

• Parole chiave di "Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• AMALIA GASTALDELLI (Persona)

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)
• Meccanismi molecolari e biologici (ME.P05.018.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Liver international (Rivista)

Insieme di parole chiave di

• Parole chiave di "Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis" (Insieme di parole chiave)