Relationship between location and size of myocardial infarction and their reciprocal influences on post-infarction left ventricular remodeling (Abstract/Comunicazione in atti di convegno)

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  • Relationship between location and size of myocardial infarction and their reciprocal influences on post-infarction left ventricular remodeling (Abstract/Comunicazione in atti di convegno) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1186/1532-429X-13-S1-P84 (literal)
Alternative label
  • Pier Giorgio Masci, Javier Ganame, Marco Francone, Walter Desmet, Valentina Lorenzoni, Ilaria Iacucci, Andrea Barison, Iacopo Carbone, Luciano Agati, Massimo Lombardi, Stefan Janssens, Jan Bogaert (2011)
    Relationship between location and size of myocardial infarction and their reciprocal influences on post-infarction left ventricular remodeling
    in 2011 SCMR/Euro CMR joint scientific sessions, Nice, France, 3 - 6 february 2011
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pier Giorgio Masci, Javier Ganame, Marco Francone, Walter Desmet, Valentina Lorenzoni, Ilaria Iacucci, Andrea Barison, Iacopo Carbone, Luciano Agati, Massimo Lombardi, Stefan Janssens, Jan Bogaert (literal)
Pagina inizio
  • P84 (literal)
Pagina fine
  • P84 (literal)
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  • ID_PUMA: cnr.ifc/2011-A6-008 (literal)
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  • http://link.springer.com/article/10.1186%2F1532-429X-13-S1-P84 (literal)
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  • 13 (literal)
Rivista
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  • S1 (literal)
Note
  • Abstract (literal)
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  • Fondazione Toscana/CNR \"G. Monasterio\", Pisa, Italy ; Gasthuisberg University Hospital, Leuven, Belgium ; La Sapienza University, Rome, Italy ; Institute of Clinical Physiology/CNR, Pisa, Italy ; Scuola Superiore S.Anna, Pisa, Italy (literal)
Titolo
  • Relationship between location and size of myocardial infarction and their reciprocal influences on post-infarction left ventricular remodeling (literal)
Abstract
  • Background Patients with anterior MI experience worse LV remodeling and dysfunction than non-anterior MI patients. It remains unclear whether this difference is due to larger MI size or whether infarct location plays a role beyond MI size. Study aim To assess the relationship between myocardial infarction (MI) location and size and their reciprocal influences on post-infarction left ventricular (LV) remodeling. Methods A cohort of 260 reperfused ST-segment elevation MI patients was studied with cardiovascular magnetic resonance (CMR) at 1-week (baseline) and 4-month (follow-up). Area at risk (AAR) and MI size were quantified by T2-weighted and late gadolinium enhancement imaging, respectively. Adverse LV remodeling was defined as increase in LV end-systolic volume >=15% at follow-up. Results One-hundred twenty-seven(49%) patients had anterior MI and 133(51%) patients had non-anterior MI. Although the degree of myocardial salvage was similar between groups (p=0.74), anterior MI patients had larger AAR and MI size than non-anterior MI patients yielding worse regional and global LV function at baseline and follow-up. At univariable analysis, anterior MI was associated with increased risk of adverse LV remodeling (p=0.017) and lower LV ejection-fraction at follow-up (p=0.001), but not when accounted for baseline MI size. Accordingly, at multivariable analysis baseline MI size but not its location was an independent predictor of adverse LV remodeling (OR=1.061, p<0.001) and ejection-fraction at follow-up (Beta-coefficient=-0.255, p<0.001). Conclusions Anterior MI patients experience more pronounced post-infarction LV remodeling and dysfunction than non-anterior MI patients due to greater magnitude of irreversible ischemic LV damage without any independent contribution of MI location. Termini liberi: myocardial infarction; cardiovascular magnetic resonance. (literal)
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