http://www.cnr.it/ontology/cnr/individuo/prodotto/ID202237
Persistence of Mortality Risk in Patients With Acute Cardiac Diseases and Mild Thyroid Dysfunction (Articolo in rivista)
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- Label
- Persistence of Mortality Risk in Patients With Acute Cardiac Diseases and Mild Thyroid Dysfunction (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1097/MAJ.0b013e31822846bd (literal)
- Alternative label
Molinaro, Sabrina[ 1 ];Iervasi, Giorgio[ 1 ]; Lorenzoni, Valentina[ 1 ]; Coceani, Michele[ 3 ]; Landi, Patrizia[ 1 ] ; Srebot, Vera[ 1 ]; Mariani, Fabio[ 1 ]; L'Abbate, Antonio[ 2 ]; Pingitore, Alessandro[ 1 ] (2012)
Persistence of Mortality Risk in Patients With Acute Cardiac Diseases and Mild Thyroid Dysfunction
in The American journal of the medical sciences (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Molinaro, Sabrina[ 1 ];Iervasi, Giorgio[ 1 ]; Lorenzoni, Valentina[ 1 ]; Coceani, Michele[ 3 ]; Landi, Patrizia[ 1 ] ; Srebot, Vera[ 1 ]; Mariani, Fabio[ 1 ]; L'Abbate, Antonio[ 2 ]; Pingitore, Alessandro[ 1 ] (literal)
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- ID_PUMA: cnr.ifc/2011-A0-106 (literal)
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- [ 1 ] CNR, Inst Clin Physiol, I-56124 Pisa, Italy; [ 2 ] Scuola Super Sant Anna, Pisa, Italy; [ 3 ] CNR, Fdn G Monasterio, Regione Toscana, Italy (literal)
- Titolo
- Persistence of Mortality Risk in Patients With Acute Cardiac Diseases and Mild Thyroid Dysfunction (literal)
- Abstract
- NTRODUCTION:: There are no studies on the long-term prognostic role of abnormal hyrotropin value in patients with acute cardiac diseases. Aim of the study was to assess the incidence and persistence of risk of cardiac and overall deaths in patients with acute cardiac diseases. METHODS:: A total of 1026 patients (mean age: 67.7 years) were divided into 4 groups: (1) euthyroid (EU, n = 579); (2) subclinical-like hypothyroidism (SLHYPO, n = 68); (3) subclinical-like hyperthyroidism (SLHYPER, n = 23) and (4) low-triiodothyronine syndrome (LowT3, n = 356). Follow-up started from the day of thyroid hormone evaluation (mean follow-up: 30 months). The events considered were cardiac and overall deaths. RESULTS:: Survival rate for cardiac death was lower in SLHYPO and in LT3 than in EU (log rank test; ? = 33.6; P < 0.001). Survival rate for overall death was lower in SLHYPO, SLHYPER and LowT3 than in EU (48.3; P < 0.001). After adjustment for several risk factors, the hazard ratio for cardiac death was higher in SLHYPO (3.65; P = 0.004) in LowT3 (1.88; P = 0.032) and in SLHYPER (4.73; P = 0.047). Hazard ratio for overall death was higher in SLHYPO (2.30; P = 0.009), in LowT3 (1.63; P = 0.017) and in SLHYPER than in EU (3.71; P = 0.004). Hazards for SLHYPO, SLHYPER and LowT3 with respect to EU were proportional over the follow-up period. CONCLUSION:: In patients with acute cardiac disease, a mildly altered thyroid status was associated with increased risk of mortality that remains constant during all the follow-up (literal)
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