BCR/ABL1 fusion transcripts generated from alternative splicing: implications for future targeted therapies in Ph+ leukaemias. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• BCR/ABL1 fusion transcripts generated from alternative splicing: implications for future targeted therapies in Ph+ leukaemias. (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Alternative label

• Chiarella P, Summa V, De Santis S, Signori E, Picardi E, Pesole G, Saglio G, Fazio VM. PMID: 22300134 (2012)
  BCR/ABL1 fusion transcripts generated from alternative splicing: implications for future targeted therapies in Ph+ leukaemias.
  in Current molecular medicine
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Chiarella P, Summa V, De Santis S, Signori E, Picardi E, Pesole G, Saglio G, Fazio VM. PMID: 22300134 (literal)

Pagina inizio

• 547 (literal)

Pagina fine

• 565 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 12 (literal)

Rivista

• Current molecular medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University Campus Bio-Medico of Rome; University of Bari; CNR-IFT; CNR-IBB; University of Turin; IRCCS Casa Sollievo Sofferenza (literal)

Titolo

• BCR/ABL1 fusion transcripts generated from alternative splicing: implications for future targeted therapies in Ph+ leukaemias. (literal)

Abstract

• Philadelphia (Ph+) positive leukaemias are an example of haematological malignant diseases where different chromosomal rearrangements involving both BCR and ABL1 genes generate a variety of chimeric proteins (BCR/ABL1 p210, p190 and p230) which are considered pathological \"biomarkers\". In addition to these three, there is a variety of fusion transcripts whose origin may depend either on diverse genetic rearrangement or on alternative/atypical splicing of the main mRNAs or on the occurrence of single-point mutations. Although the therapy of Ph+ leukaemias based on Imatinib represents a triumph of medicine, not all patients benefit from such drug and may show resistance and intolerance. Furthermore, interruption of Imatinib administration is often followed by clinical relapse, suggesting a failure in the eradication of residual leukaemic stem cells. Therefore, while the targeted therapy is searching for new and implemented pharmacological inhibitors covering all the possible mutations in the kinase domain, there is urge to identify alternative molecular targets to develop other specific and effective therapeutic approaches. In this review we discuss the importance of recent advances based on the discovery of novel BCR/ABL1 variants and their potential role as new targets/biomarkers of Ph+ leukaemias in the light of the current therapeutic trends. The limits of the pharmacological inhibitors used for treating the disease can be overcome by considering other targets than the kinase enzyme. Our evaluations highlight the potential of alternative perspectives in the therapy of Ph+ leukaemias. (literal)

Prodotto di

• Progettazione di molecole ad attività farmacologica e loro trasferimento in vitro e in vivo mediante elettropermeabilizzazione (ME.P06.031.002) (Modulo)

Autore CNR

• GRAZIANO PESOLE (Unità di personale interno)
• EMANUELA SIGNORI (Unità di personale interno)

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• Parole chiave di "BCR/ABL1 fusion transcripts generated from alternative splicing: implications for future targeted therapies in Ph+ leukaemias." (Insieme di parole chiave)

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Autore CNR di

• EMANUELA SIGNORI (Unità di personale interno)
• GRAZIANO PESOLE (Unità di personale interno)

Prodotto

• Progettazione di molecole ad attività farmacologica e loro trasferimento in vitro e in vivo mediante elettropermeabilizzazione (ME.P06.031.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Current molecular medicine (Rivista)

Insieme di parole chiave di

• Parole chiave di "BCR/ABL1 fusion transcripts generated from alternative splicing: implications for future targeted therapies in Ph+ leukaemias." (Insieme di parole chiave)