Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems (Articolo in rivista)

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  • Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/cdd.2011.141 (literal)
Alternative label
  • Cesca F; Yabe A; Spencer-Dene B; Scholz-Starke J; Medrihan L; Maden CH; Gerhardt H; Orriss IR; Baldelli P; Al-Qatari M; Koltzenburg M; Adams RH; Benfenati F; Schiavo G (2012)
    Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems
    in Cell death and differentiation; Nature Publishing Group, London (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cesca F; Yabe A; Spencer-Dene B; Scholz-Starke J; Medrihan L; Maden CH; Gerhardt H; Orriss IR; Baldelli P; Al-Qatari M; Koltzenburg M; Adams RH; Benfenati F; Schiavo G (literal)
Pagina inizio
  • 194 (literal)
Pagina fine
  • 208 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.nature.com/cdd/journal/v19/n2/full/cdd2011141a.html (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 19 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Italian Inst Technol, Dept Neurosci & Brain Technol, I-16163 Genoa, Italy; Canc Res UK London Res Inst, Mol Neuropathol Lab, London WC2A 3LY, England; Canc Res UK London Res Inst, Expt Pathol Lab, London WC2A 3LY, England; UCL, Inst Ophthalmol, London EC1V 9EL, England; Canc Res UK London Res Inst, Vasc Biol Lab, London WC2A 3LY, England; UCL, Dept Cell & Dev Biol, London WC1E 6BT, England; UCL, Inst Child Hlth, London WC1N 1EH, England; Max Planck Inst Mol Biomed, D-48149 Munster, Germany (literal)
Titolo
  • Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems (literal)
Abstract
  • Signaling downstream of receptor tyrosine kinases controls cell differentiation and survival. How signals from different receptors are integrated is, however, still poorly understood. In this work, we have identified Kidins220 (Kinase D interacting substrate of 220 kDa)/ARMS (Ankyrin repeat-rich membrane spanning) as a main player in the modulation of neurotrophin and vascular endothelial growth factor (VEGF) signaling in vivo, and a primary determinant for neuronal and cardiovascular development. Kidins220-/- embryos die at late stages of gestation, and show extensive cell death in the central and peripheral nervous systems. Primary neurons from Kidins220-/- mice exhibit reduced responsiveness to brain-derived neurotrophic factor, in terms of activation of mitogen-activated protein kinase signaling, neurite outgrowth and potentiation of excitatory postsynaptic currents. In addition, mice lacking Kidins220 display striking cardiovascular abnormalities, possibly due to impaired VEGF signaling. In support of this hypothesis, we demonstrate that Kidins220 constitutively interacts with VEGFR2. These findings, together with the data presented in the accompanying paper, indicate that Kidins220 mediates the integration of several growth factor receptor pathways during development, and mediates the activation of distinct downstream cascades according to the location and timing of stimulation. (literal)
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