Phase Behaviour, Structure and Surface Rheology of Mixed Lipid-Nanoparticle Layers (Abstract/Poster in atti di convegno)

Type
Label
  • Phase Behaviour, Structure and Surface Rheology of Mixed Lipid-Nanoparticle Layers (Abstract/Poster in atti di convegno) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Libero Liggieri, Michele Ferrari, Eduardo Guzman, Eva Santini, Francesca Ravera (2012)
    Phase Behaviour, Structure and Surface Rheology of Mixed Lipid-Nanoparticle Layers
    in 5th International Workshop Bubble and Drop Interfaces, Krakov, Poland
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Libero Liggieri, Michele Ferrari, Eduardo Guzman, Eva Santini, Francesca Ravera (literal)
Note
  • Poster (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR - Istituto per l'Energetica e le Interfasi, Genova (Italy) (literal)
Titolo
  • Phase Behaviour, Structure and Surface Rheology of Mixed Lipid-Nanoparticle Layers (literal)
Abstract
  • Lipid layers at the aqueous interface have been extensively investigated in relation to different biological systems, such as models for the pulmonary surfactants or for cell membranes. Studying the interaction of these layers with nanoparticles (NP) is therefore of great importance as a first approach to understand the interaction of NPs with living systems and more generally to develop innovative biomaterials. We focus here on the results of our recent studies on the interfacial properties of mixed lipid- NP systems, based on a set of experimental tools. Langmuir trough was utilized to investigate the modifications induced by NPs on the phase behavior of spread lipid layers. The above information were complemented by those on the lateral and vertical structure of these mixed layers accessed by Brewster Angle microscopy and Ellipsometry. Finally, the mechanical features of these mixed layers were investigated by the Oscillating Barrier method in the Langmuir trough and by the Oscillating Bubble method in a drop shape tensiometer. Specifically, the study addressed the interactions of nanometric colloidal silica and carbonaceous particles, such as carbon black and soot, with mixtures of lipids simulating the pulmonary surfactants (DPPC, DOPC, Palmic acid). Depending on the systems and on the conditions, the results have evidenced a variety of complex interactions between the particles and the lipids, such as lipid sequestration via adsorption at the particle surface or particle incorporation in the monolayer. As concerned to the effects of NPs on the simulated pulmonary surfactant, these studies provided the definition of parameters which could be suitably utilised to score NPs for their potential adverse impact on the respiratory physiology. Literature: Guzmán Eduardo, Liggieri Libero, Santini Eva, Ferrari Michele, Ravera Francesca.2012. DPPC-DOPC Langmuir monolayers modified by hydrophilic silica nanoparticles: Phase behaviour, structure and rheology. Colloids Surf. A. doi:10.1016/j.colsurfa.2011.12.059 Santini Eva, Guzman Eduardo, Ravera Francesca, Ferrari Michele, Liggieri Libero. 2012. Properties and structure of interfacial layers formed by hydrophilic silica dispersions and palmitic acid. Phys. Chem. Chem. Phys. 14: 607-615 Guzman Eduardo, Liggieri Libero, Santini Eva, Ferrari Michele, Ravera Francesca. 2011. Effect of Hydrophilic and Hydrophobic Nanoparticles on the Surface Pressure Response of DPPC Monolayers. J. Phys. Chem. C 115: 21715-21722 (literal)
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