http://www.cnr.it/ontology/cnr/individuo/prodotto/ID201564
Nanocomposites for Multimodal Molecular Imaging (Contributo in atti di convegno)
- Type
- Label
- Nanocomposites for Multimodal Molecular Imaging (Contributo in atti di convegno) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Alternative label
Sergio Casciaro, Antonio Greco, Ernesto Casciaro, Francesco Conversano, Aimè Lay-Ekuakille (2011)
Nanocomposites for Multimodal Molecular Imaging
in 10. IEEE Conference on Sensors, Limerick, Ireland, OCT 28-31, 2011
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Sergio Casciaro, Antonio Greco, Ernesto Casciaro, Francesco Conversano, Aimè Lay-Ekuakille (literal)
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- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
- ID_PUMA: cnr.ifc/2011-A2-015 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://ieeexplore.ieee.org/xpl/articleDetails.jsp?reload=true&arnumber=6127395 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume
- 2011 IEEE Sensors (literal)
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- ISI Web of Science (WOS) (literal)
- Scopu (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- National Research Council, Bioengineering Division, Institute of Clinical Physiology, Lecce, Italy ; Department of Innovation Engineering, University of Salento, Lecce, Italy (literal)
- Titolo
- Nanocomposites for Multimodal Molecular Imaging (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#isbn
- Abstract
- Early and accurate diagnosis of tumors requires the combined adoption of different imaging modalities with molecular sensitivity. A successful employment of multimodal molecular imaging is related to the development of smart fully-biodegradable nanoparticle contrast agents (NPCAs), detectable by at least two non-ionizing imaging techniques and suitably sized for tumor targeting. After a short overview of recent findings obtained by our research group in the development and characterization of novel NPCAs, this paper shows for the first time a quantitative assessment of the effectiveness of both a pure silica NPCA and a composite silica/superparamagnetic NPCA as scatterers of low-frequency diagnostic ultrasound (3 MHz) in very low volume concentrations (0.1-0.2%). The pure silica NPCA confirmed the behavior recently reported for higher concentrations at higher frequencies. The composite NPCA followed the same behavior, showing a marked effectiveness peak for a particle diameter of 330 nm, which represents a particularly useful size for tumor targeting purposes. These results open new exciting perspectives for dual-mode molecular imaging of deep tumors, combining ultrasound and magnetic resonance techniques for the accurate, safe and early detection of cancer cells located in internal organs. (literal)
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