Nanocomposites for Multimodal Molecular Imaging (Contributo in atti di convegno)

Type
Label
  • Nanocomposites for Multimodal Molecular Imaging (Contributo in atti di convegno) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • Sergio Casciaro, Antonio Greco, Ernesto Casciaro, Francesco Conversano, Aimè Lay-Ekuakille (2011)
    Nanocomposites for Multimodal Molecular Imaging
    in 10. IEEE Conference on Sensors, Limerick, Ireland, OCT 28-31, 2011
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Sergio Casciaro, Antonio Greco, Ernesto Casciaro, Francesco Conversano, Aimè Lay-Ekuakille (literal)
Pagina inizio
  • 837 (literal)
Pagina fine
  • 840 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • ID_PUMA: cnr.ifc/2011-A2-015 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://ieeexplore.ieee.org/xpl/articleDetails.jsp?reload=true&arnumber=6127395 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume
  • 2011 IEEE Sensors (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • National Research Council, Bioengineering Division, Institute of Clinical Physiology, Lecce, Italy ; Department of Innovation Engineering, University of Salento, Lecce, Italy (literal)
Titolo
  • Nanocomposites for Multimodal Molecular Imaging (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#isbn
  • 9781424492893 (literal)
Abstract
  • Early and accurate diagnosis of tumors requires the combined adoption of different imaging modalities with molecular sensitivity. A successful employment of multimodal molecular imaging is related to the development of smart fully-biodegradable nanoparticle contrast agents (NPCAs), detectable by at least two non-ionizing imaging techniques and suitably sized for tumor targeting. After a short overview of recent findings obtained by our research group in the development and characterization of novel NPCAs, this paper shows for the first time a quantitative assessment of the effectiveness of both a pure silica NPCA and a composite silica/superparamagnetic NPCA as scatterers of low-frequency diagnostic ultrasound (3 MHz) in very low volume concentrations (0.1-0.2%). The pure silica NPCA confirmed the behavior recently reported for higher concentrations at higher frequencies. The composite NPCA followed the same behavior, showing a marked effectiveness peak for a particle diameter of 330 nm, which represents a particularly useful size for tumor targeting purposes. These results open new exciting perspectives for dual-mode molecular imaging of deep tumors, combining ultrasound and magnetic resonance techniques for the accurate, safe and early detection of cancer cells located in internal organs. (literal)
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