http://www.cnr.it/ontology/cnr/individuo/prodotto/ID201546
Subnormothermic machine perfusion for non-heart-beating donor liver grafts preservation in a Swine model: a new strategy to increase the donor pool? (Articolo in rivista)
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- Subnormothermic machine perfusion for non-heart-beating donor liver grafts preservation in a Swine model: a new strategy to increase the donor pool? (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.transproceed.2012.06.014. (literal)
- Alternative label
Gringeri E, Bonsignore P, Bassi D, D'Amico FE, Mescoli C, Polacco M, Buggio M, Luisetto R, Boetto R, Noaro G, Ferrigno A, Boncompagni E, Freitas I, Vairetti MP, Carraro A, Neri D, Cillo U. (2012)
Subnormothermic machine perfusion for non-heart-beating donor liver grafts preservation in a Swine model: a new strategy to increase the donor pool?
in Transplantation proceedings
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Gringeri E, Bonsignore P, Bassi D, D'Amico FE, Mescoli C, Polacco M, Buggio M, Luisetto R, Boetto R, Noaro G, Ferrigno A, Boncompagni E, Freitas I, Vairetti MP, Carraro A, Neri D, Cillo U. (literal)
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- http://www.sciencedirect.com/science/article/pii/S004113451200557X (literal)
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- ISI Web of Science (WOS) (literal)
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- Department of General Surgery and Organ Transplantation, Hepatobiliary Surgery and Liver Transplantation Unit, University of Padova, Padova, Italy; Department of Medical Diagnostic Sciences and Special Therapies, University of Padova, Padova, Italy; Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; Department of Animal Biology ang IGM-CNR, Histochemistry and Citometry Section, University of Pavia, Pavia, Italy (literal)
- Titolo
- Subnormothermic machine perfusion for non-heart-beating donor liver grafts preservation in a Swine model: a new strategy to increase the donor pool? (literal)
- Abstract
- We previously reported that subnormothermic machine perfusion (sMP; 20°C) is able to improve the preservation of livers obtained from non-heart-beating donors (NHBDs) in rats. We have compared sMP and standard cold storage (CS) to preserve pig livers after 60 minutes of cardiac arrest. In the sMP group livers were perfused for 6 hours with Celsior at 20°C. In the CS group they were stored in Celsior at 4°C for 6 hours as usual. To simulate liver transplantation, both sMP- and CS-preserved livers were reperfused using a mechanical continuous perfusion system with autologus blood for 2 hours at 37°C. At 120 min after reperfusion aspartate aminotransferase levels in sMP versus CS were 499 ± 198 versus 7648 ± 2806 U/L (P <.01); lactate dehydrogenase 1685 ± 418 versus 12998 ± 3039 U/L (P <.01); and lactic acid 4.78 ± 3.02 versus 10.46 ± 1.79 mmol/L (P <.01) respectively. The sMP group showed better histopathologic results with significantly less hepatic damage. This study confirmed that sMP was able to resuscitate liver grafts from large NHBD animals. © 2012 Elsevier Inc. All rights reserved. (literal)
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