Lobe-specific heterogeneity and matrix metalloproteinase activation after ischemia/reperfusion injury in rat livers (Articolo in rivista)

Type
Label
  • Lobe-specific heterogeneity and matrix metalloproteinase activation after ischemia/reperfusion injury in rat livers (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1177/0192623312441403 (literal)
Alternative label
  • Palladini G, Ferrigno A, Rizzo V, Boncompagni E, Richelmi P, Freitas I, Perlini S, Vairetti M. (2012)
    Lobe-specific heterogeneity and matrix metalloproteinase activation after ischemia/reperfusion injury in rat livers
    in Toxicologic pathology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Palladini G, Ferrigno A, Rizzo V, Boncompagni E, Richelmi P, Freitas I, Perlini S, Vairetti M. (literal)
Pagina inizio
  • 722 (literal)
Pagina fine
  • 730 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://tpx.sagepub.com/content/40/5/722.long (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 40 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 5 (literal)
Note
  • Scopu (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Internal Medicine and Therapeutics, University of Pavia, Italy; Department of Biochemistry, University of Pavia, Italy; Department of Biology and Biotechnology \"Lazzaro Spallanzani\" IGM-CNR, Histochemistry and Cytometry Section, University of Pavia, Italy (literal)
Titolo
  • Lobe-specific heterogeneity and matrix metalloproteinase activation after ischemia/reperfusion injury in rat livers (literal)
Abstract
  • Studies assessing the effects of partial-hepatic ischemia/reperfusion (I/R) injury focused on the damage to the ischemic-lobe, whereas few data are available on non-ischemic lobe. This study investigated whether acute liver I/R does affect non-ischemic lobe function via modulation of extracellular matrix remodeling. Male Sprague-Dawley rats underwent left lateral- and median-lobe ischemia for 30 min and reperfusion for 60 min or sham operation. After reperfusion, blood samples and hepatic biopsies from both the ischemic (left-lobe, LL) and the non-ischemic lobe (right-lobe, RL) were collected. Serum hepatic enzymes and TNF-alpha, tissue matrix metalloproteinases (MMP-2, MMP-9), liver morphology, malondialdehyde (MDA), and myeloperoxidase (MPO) were evaluated. Liver I/R injury was confirmed by altered increased hepatic enzymes and TNF-alpha. I/R induced an altered morphology and an increase in MMP-2 and MMP-9 activity not only in left-ischemic lobe (LL) but also in the right-non-ischemic (RL) lobe. A lobar difference was detected for MDA formation and MPO activity in both sham and I/R submitted rats, with higher levels in the left lobe for both groups. This study indicates that an increase in MMPs, which may be TNF-alpha-mediated, occurs in both the ischemic- and the non-ischemic lobes; the heterogeneous lobe concentrations of MDA and MPO suggest that the random sampling of liver tissue should be avoided. © 2012 by The Author(s). (literal)
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