http://www.cnr.it/ontology/cnr/individuo/prodotto/ID201540
Lobe-specific heterogeneity and matrix metalloproteinase activation after ischemia/reperfusion injury in rat livers (Articolo in rivista)
- Type
- Label
- Lobe-specific heterogeneity and matrix metalloproteinase activation after ischemia/reperfusion injury in rat livers (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1177/0192623312441403 (literal)
- Alternative label
Palladini G, Ferrigno A, Rizzo V, Boncompagni E, Richelmi P, Freitas I, Perlini S, Vairetti M. (2012)
Lobe-specific heterogeneity and matrix metalloproteinase activation after ischemia/reperfusion injury in rat livers
in Toxicologic pathology (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Palladini G, Ferrigno A, Rizzo V, Boncompagni E, Richelmi P, Freitas I, Perlini S, Vairetti M. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://tpx.sagepub.com/content/40/5/722.long (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- Scopu (literal)
- PubMe (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Department of Internal Medicine and Therapeutics, University of Pavia, Italy; Department of Biochemistry, University of Pavia, Italy; Department of Biology and Biotechnology \"Lazzaro Spallanzani\" IGM-CNR, Histochemistry and Cytometry Section, University of Pavia, Italy (literal)
- Titolo
- Lobe-specific heterogeneity and matrix metalloproteinase activation after ischemia/reperfusion injury in rat livers (literal)
- Abstract
- Studies assessing the effects of partial-hepatic ischemia/reperfusion (I/R) injury focused on the damage to the ischemic-lobe, whereas few data are available on non-ischemic lobe. This study investigated whether acute liver I/R does affect non-ischemic lobe function via modulation of extracellular matrix remodeling. Male Sprague-Dawley rats underwent left lateral- and median-lobe ischemia for 30 min and reperfusion for 60 min or sham operation. After reperfusion, blood samples and hepatic biopsies from both the ischemic (left-lobe, LL) and the non-ischemic lobe (right-lobe, RL) were collected. Serum hepatic enzymes and TNF-alpha, tissue matrix metalloproteinases (MMP-2, MMP-9), liver morphology, malondialdehyde (MDA), and myeloperoxidase (MPO) were evaluated. Liver I/R injury was confirmed by altered increased hepatic enzymes and TNF-alpha. I/R induced an altered morphology and an increase in MMP-2 and MMP-9 activity not only in left-ischemic lobe (LL) but also in the right-non-ischemic (RL) lobe. A lobar difference was detected for MDA formation and MPO activity in both sham and I/R submitted rats, with higher levels in the left lobe for both groups. This study indicates that an increase in MMPs, which may be TNF-alpha-mediated, occurs in both the ischemic- and the non-ischemic lobes; the heterogeneous lobe concentrations of MDA and MPO suggest that the random sampling of liver tissue should be avoided. © 2012 by The Author(s). (literal)
- Prodotto di
- Autore CNR
- Insieme di parole chiave
Incoming links:
- Prodotto
- Autore CNR di
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
- Insieme di parole chiave di