Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population (Articolo in rivista)

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  • Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1111/j.1365-2796.2011.02442.x (literal)
Alternative label
  • Handberg, Aase [1,2]; Hojlund, Kurt [3]; Gastaldelli, Amalia [4]; Flyvbjerg, Alan [5] ; Dekker, Jacqueline M. [6] ; Petrie, John [7]; Piatti, Piermarco [ 8 ] ; Beck-Nielsen, Henning [3] (2012)
    Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population
    in Journal of internal medicine (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Handberg, Aase [1,2]; Hojlund, Kurt [3]; Gastaldelli, Amalia [4]; Flyvbjerg, Alan [5] ; Dekker, Jacqueline M. [6] ; Petrie, John [7]; Piatti, Piermarco [ 8 ] ; Beck-Nielsen, Henning [3] (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • ID_PUMA: cnr.ifc/2011-A0-094 (literal)
Rivista
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  • 11 (literal)
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  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
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  • [ 1 ] Aarhus Univ Hosp, Dept Clin Biochem, Aarhus Hosp, DK-8000 Aarhus, Denmark; [ 2 ] Aarhus Univ Hosp, Aalborg Hosp, DK-8000 Aarhus, Denmark; [ 3 ] Odense Univ Hosp, Dept Endocrinol M, DK-5000 Odense, Denmark; [ 4 ] CNR, Inst Clin Physiol, I-56100 Pisa, Italy; [ 5 ] Aarhus Univ Hosp, Dept Endocrinol, DK-8000 Aarhus, Denmark; [ 6 ] Vrije Univ Amsterdam, EMGO Inst, Amsterdam, Netherlands; [ 7 ] BHF Glasgow Cardiovasc Res Ctr, Glasgow, Lanark, Scotland; [ 8 ] San Raffaele Inst, Dept Metab Dis, Milan, Italy (literal)
Titolo
  • Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population (literal)
Abstract
  • Handberg A, Hojlund K, Gastaldelli A, Flyvbjerg A, Dekker JM, Petrie J, Piatti P, Beck-Nielsen H (Aarhus Hospital and Aalborg Hospital, Aarhus University Hospital, Aarhus, Denmark; Odense University Hospital, Odense, Denmark; Institute of Clinical Physiology, CNR Pisa, Pisa, Italy; Aarhus University Hospital, Aarhus, Denmark; Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; BHF Glasgow Cardiovascular Research Centre, Glasgow, UK; and San Raffaele Institute, Milan, Italy). Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population. J Intern Med 2011; doi: 10.1111/j.1365-2796.2011.02442.x. Objectives. Insulin resistance is associated with increased CD36 expression in a number of tissues. Moreover, excess macrophage CD36 may initiate atherosclerotic lesions. The aim of this study was to determine whether plasma soluble CD36 (sCD36) was associated with insulin resistance, fatty liver and carotid atherosclerosis in nondiabetic subjects. Methods. In 1296 healthy subjects without diabetes or hypertension recruited from 19 centres in 14 European countries (RISC study), we determined the levels of sCD36, adiponectin, lipids and liver enzymes, insulin sensitivity (M/I) by euglycaemic-hyperinsulinaemic clamp, carotid atherosclerosis as intima-media thickness (IMT) and two estimates of fatty liver, the fatty liver index (FLI) and liver fat percentage (LF%). Results. IMT, FLI, LF%, presence of the metabolic syndrome, impaired glucose regulation, insulin and triglycerides increased across sCD36 quartiles (Q2-Q4), whereas adiponectin and M/I decreased (P (literal)
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