Results of Vardenafil Mediated Power Doppler Ultrasound, Contrast Enhanced Ultrasound and Systematic Random Biopsies to Detect Prostate Cancer (Articolo in rivista)

Type
Label
  • Results of Vardenafil Mediated Power Doppler Ultrasound, Contrast Enhanced Ultrasound and Systematic Random Biopsies to Detect Prostate Cancer (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.juro.2011.02.014 (literal)
Alternative label
  • Morelli, G (Morelli, Girolamo)[ 1 ] ; Pagni, R (Pagni, Riccardo)[ 1 ] ; Mariani, C (Mariani, Chiara)[ 1 ] ; Minervini, R (Minervini, Riccardo)[ 1 ] ; Morelli, A (Morelli, Andrea)[ 1 ] ; Gori, F (Gori, Francesco)[ 2 ] ; Ferdeghini, EM (Ferdeghini, Ezio Maria)[ 4 ] ; Paterni, M (Paterni, Marco)[ 4 ] ; Mauro, E (Mauro, Eva)[ 3 ] ; Guidi, E (Guidi, Elisa)[ 3 ] ; Armillotta, N (Armillotta, Nicola)[ 3 ] ; Canale, D (Canale, Domenico)[ 3,5 ] ; Vitti, P (Vitti, Paolo)[ 5 ] ; Caramella, D (Caramella, Davide)[ 3,5 ] ; Minervini, A (Minervini, Andrea)[ 6 ] (2011)
    Results of Vardenafil Mediated Power Doppler Ultrasound, Contrast Enhanced Ultrasound and Systematic Random Biopsies to Detect Prostate Cancer
    in The Journal of urology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Morelli, G (Morelli, Girolamo)[ 1 ] ; Pagni, R (Pagni, Riccardo)[ 1 ] ; Mariani, C (Mariani, Chiara)[ 1 ] ; Minervini, R (Minervini, Riccardo)[ 1 ] ; Morelli, A (Morelli, Andrea)[ 1 ] ; Gori, F (Gori, Francesco)[ 2 ] ; Ferdeghini, EM (Ferdeghini, Ezio Maria)[ 4 ] ; Paterni, M (Paterni, Marco)[ 4 ] ; Mauro, E (Mauro, Eva)[ 3 ] ; Guidi, E (Guidi, Elisa)[ 3 ] ; Armillotta, N (Armillotta, Nicola)[ 3 ] ; Canale, D (Canale, Domenico)[ 3,5 ] ; Vitti, P (Vitti, Paolo)[ 5 ] ; Caramella, D (Caramella, Davide)[ 3,5 ] ; Minervini, A (Minervini, Andrea)[ 6 ] (literal)
Pagina inizio
  • 2126 (literal)
Pagina fine
  • 2131 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 185 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 6 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • [ 1 ] Univ Pisa, Urol Unit, Dept Surg, New Santa Chiara Hosp Cisanello, Pisa, Italy [ 2 ] Univ Pisa, Dept Math & Stat, Pisa, Italy [ 3 ] Univ Pisa, Dept Radiol, Santa Chiara Hosp, Pisa, Italy [ 4 ] CNR, Inst Clin Physiol, Pisa, Italy [ 5 ] New Santa Chiara Hosp Cisanello, Dept Androl, Pisa, Italy [ 6 ] Univ Florence, Dept Urol, Careggi Hosp, Florence, Italy (literal)
Titolo
  • Results of Vardenafil Mediated Power Doppler Ultrasound, Contrast Enhanced Ultrasound and Systematic Random Biopsies to Detect Prostate Cancer (literal)
Abstract
  • Purpose: We evaluated the ability of the phosphodiesterase-5 inhibitor vardenafil to increase prostate microcirculation during power Doppler ultrasound. We also evaluated the results of contrast and vardenafil enhanced targeted biopsies compared to those of standard 12-core random biopsies to detect cancer. Materials and Methods: Between May 2008 and January 2010, 150 consecutive patients with prostate specific antigen more than 4 ng/ml at first diagnosis with negative digital rectal examination and transrectal ultrasound, and no clinical history of prostatitis underwent contrast enhanced power Doppler ultrasound (bolus injection of 2.4 ml SonoVue (R) contrast agent), followed by vardenafil enhanced power Doppler ultrasound (1 hour after oral administration of vardenafil 20 mg). All patients underwent standard 12-core transrectal ultrasound guided random prostate biopsy plus 1 further sampling from each suspected hypervascular lesion detected by contrast and vardenafil enhanced power Doppler ultrasound. Results: Prostate cancer was detected in 44 patients (29.3%). Contrast and vardenafil enhanced power Doppler ultrasound detected suspicious, contrast enhanced and vardenafil enhanced areas in 112 (74.6%) and 110 patients (73.3%), and was diagnostic for cancer in 32 (28.5%) and 42 (38%), respectively. Analysis of standard technique, and contrast and vardenafil enhanced power Doppler ultrasound findings by biopsy core showed significantly higher detection using vardenafil vs contrast enhanced power Doppler ultrasound and standard technique (41.2% vs 22.7% and 8.1%, p < 0.005 and <0.001, respectively). The detection rate of standard plus contrast or vardenafil enhanced power Doppler ultrasound was 10% and 11.7% (p not significant). (literal)
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