Relationship between fatty liver and glucose metabolism: A cross-sectional study in 571 obese children (Articolo in rivista)

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  • Relationship between fatty liver and glucose metabolism: A cross-sectional study in 571 obese children (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.numecd.2010.05.003 (literal)
Alternative label
  • Bedogni, G [ 2,3,4 ] ; Gastaldelli, A [ 1 ] ; Manco, M [ 5 ] ; De Col, A [ 6,7,8 ] ; Agosti, F [ 6,7,8 ] ; Tiribelli, C [ 2,3 ] ; Sartorio, A [ 6,7,8,9 ] (2012)
    Relationship between fatty liver and glucose metabolism: A cross-sectional study in 571 obese children
    in NMCD. Nutrition Metabolism and Cardiovascular Diseases (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bedogni, G [ 2,3,4 ] ; Gastaldelli, A [ 1 ] ; Manco, M [ 5 ] ; De Col, A [ 6,7,8 ] ; Agosti, F [ 6,7,8 ] ; Tiribelli, C [ 2,3 ] ; Sartorio, A [ 6,7,8,9 ] (literal)
Pagina inizio
  • 120 (literal)
Pagina fine
  • 126 (literal)
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  • 22 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • [ 1 ] CNR, IFC, Pisa, Italy [ 2 ] Ctr Studi Fegato, Basovizza, Italy [ 3 ] Univ Trieste, Dipartimento ACADEM, Trieste, Italy [ 4 ] Univ Milan, Fdn IRCCS Ca Granda, Osped Maggiore Policlin, Dipartimento Sci Materne & Pediat, Milan, Italy [ 5 ] Osped Pediat Bambino Gesu, Direz Sci, IRCCS, Rome, Italy [ 6 ] IRCCS, Ist Auxol Italiano, Lab Sperimentale Ric Auxoendocrinol, Milan, Italy [ 7 ] IRCCS, Ist Auxol Italiano, Lab Sperimentale Ric Auxoendocrinol, Oggebbio, Italy [ 8 ] IRCCS, Ist Auxol Italiano, Lab Sperimentale Ric Auxoendocrinol, Verbania, Italy [ 9 ] IRCCS, Ist Auxol Italiano, Div Auxol, Oggebbio, Verbania, Italy (literal)
Titolo
  • Relationship between fatty liver and glucose metabolism: A cross-sectional study in 571 obese children (literal)
Abstract
  • Background and aims: Early onset type 2 diabetes mellitus (T2DM) is associated with obesity, insulin resistance and impaired beta-cell function. Non-alcoholic fatty liver disease (NAFLD) may be an independent risk factor for T2DM. We investigated the relationship between NAFLD and glucose metabolism in a large sample of obese children. Methods and Results: A total of 571 obese children (57% males and 43% females) aged 8-18 years were consecutively studied at a tertiary care centre specialised in paediatric obesity. Liver ultrasonography was used to diagnose NAFLD after exclusion of hepatitis B and C and alcohol consumption. Oral-glucose tolerance testing (OGTT) was performed; insulin sensitivity was evaluated by using the insulin sensitivity index (ISI) and beta-cell function by using the ratio between the incremental areas under the curve (AUC) of insulin and glucose (incAUCins/incAUCglu). A total of 41% of the obese children had NAFLD. Impaired glucose tolerance or T2DM was present in 25% of the children with NAFLD versus 8% of those without it (p < 0.001). Children with NAFLD had higher body mass index (BMI), fasting glucose, 120-min OGTT glucose, incAUCins/incAUCglu and lower ISI as compared with children without NAFLD (p <= 0.002). At bootstrapped multivariable median regression analysis controlling for gender, age, pubertal status and BMI, NAFLD was an independent predictor of 120-min OGTT glucose and ISI, but not of incAUCins/incAUCglu. Similar findings were obtained using continuous liver steatosis as the predictor, instead of dichotomous NAFLD. (literal)
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