http://www.cnr.it/ontology/cnr/individuo/prodotto/ID201011
Cellular and molecular stress induced by chemical and physical agents in sea urchins (Abstract/Comunicazione in atti di convegno)
- Type
- Label
- Cellular and molecular stress induced by chemical and physical agents in sea urchins (Abstract/Comunicazione in atti di convegno) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Alternative label
V. Matranga, R. Bonaventura, C. Costa,K. Karakostis, C. Martino, A. Pinsino, R.
Russo, F. Zito (2012)
Cellular and molecular stress induced by chemical and physical agents in sea urchins
in 5th Bilateral Seminar Italy Japan, Area della Ricerca- CNR- Palermo, 27-29/12
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- V. Matranga, R. Bonaventura, C. Costa,K. Karakostis, C. Martino, A. Pinsino, R.
Russo, F. Zito (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.ibim.cnr.it/bsij12/index.html (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume
- Book of abstracts -5th Bilateral Seminar Italy-Japan (literal)
- Note
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto di Biomedicina e Immunologia Molecolare, \"Alberto Monroy\", Consiglio Nazionale delle Ricerche, via
U.La Malfa 153, 90146, Palermo, Italy (literal)
- Titolo
- Cellular and molecular stress induced by chemical and physical agents in sea urchins (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#isbn
- Abstract
- Our research group has been classically involved in basic research studies on echinoderms, including
the sea star Asteria rubens, the sea urchin Arbacia lixula and overall the Mediterranean sea urchin
Paracentrotus lividus, the best known European established model system for studies on embryonic
development.
The sea urchin embryo is a suitable model for the assessment of cellular responses to physical and
chemical stresses at genomic and proteomic levels, since it has a complex network of genes involved
in response, protection and repair of cellular damage. In particular, our interest is devoted to the
identification of the molecular pathways involved in the stress response to environmental stimuli, such
as ionizing radiations [1,2,3] or heavy metals [4,5]. Physical and chemical agents used in these studies
are: UV-B, X-Rays, CdCl2, MnCl2, pH, Temperature, Mg deprivation. Results from this line of
investigation are interesting from an ecotoxicological point of view, as they can have a predictive
value in terms of protection of marine ecosystems. Lately, we focused our attention on the stress
response of the sea urchin embryos to the combined effects of UV-B radiation and Cd exposure, at
cellular, molecular and biochemical level. We obtained promising results indicating a sinergistic effect
of two different agents. Moreover, sea urchin embryos cultured in Mg-Free sea water show abnormal
differentiation patterns and stress response.
In recent years we developed an interest for the understanding of basic mechanisms involved in bio-
mineralization processes of sea urchin embryos and adults. Bio-mineralization, i.e. the formation of
bio-nano-structured minerals by living cells, is an attractive area of the nano(bio)technologies. In
particular, we have now identified a number of genes involved in the formation of the magnesium
calcite skeleton of embryos, and we are monitoring their expression during physiological development
or in pathological conditions, namely in skeleton-deficient embryos [6].
Taken all together, results described so far encourage the use of echinoderms for ecotoxicological
studies and development of biomarkers. They can be used for fast, low-cost and reliable screening and
testing of toxic agents. Results may provide important future directions for studies on environmental
and human health.
References
1. Bonaventura R, Poma V, Costa C, Matranga V (2005) UVB radiation prevents skeleton growth and
stimulates the expression of stress markers in sea urchin embryos. BBRC 328: 150-157
2. Matranga V, Zito F, Costa C, Bonaventura R, Giarrusso S, Celi F (2010) Embryonic development and
skeletogenic gene expression affected by X-rays in the Mediterranean sea urchin Paracentrotus lividus.
Ecotoxicology 19: 530-537
3. Russo R, Zito F, Costa C, Bonaventura R, Matranga V (2010) Transcriptional increase and misexpression of
14-3-3 epsilon in sea urchin embryos exposed to UV-B. Cell Stress & Chaperones 15, 993-1001
4. Russo R, Bonaventura R, Zito F, Schröder HC, Müller I, Müller WE, Matranga V (2003) Stress to cadmium
monitored by metallothionein gene induction in Paracentrotus lividus embryos. Cell Stress Chaperones 8: 232-
241
5. Pinsino A, Matranga V, Trinchella F, Roccheri MC (2010) Sea urchin embryos as an in vivo model for the
assessment of manganese toxicity: developmental and stress response effects. Ecotoxicology 19: 555-562
6. Costa C, Karakostis K, Zito F, Matranga V (2012) Phylogenetic analysis and expression patterns of p16 and
p19 in P.lividus embryos. Dev. Genes. Evol. 222, 245-251 (literal)
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