Knockout of pgdS and ggt genes improves ?-PGA yield in B. subtilis (Articolo in rivista)

Type
Label
  • Knockout of pgdS and ggt genes improves ?-PGA yield in B. subtilis (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/bit.24846 (literal)
Alternative label
  • Scoffone V, Dondi D, Biino G, Borghese G, Pasini D, Galizzi A, Calvio C. (2013)
    Knockout of pgdS and ggt genes improves ?-PGA yield in B. subtilis
    in Biotechnology and bioengineering (Online); Wiley, New York (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Scoffone V, Dondi D, Biino G, Borghese G, Pasini D, Galizzi A, Calvio C. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://onlinelibrary.wiley.com/doi/10.1002/bit.24846/abstract (literal)
Rivista
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dept. of Biology and Biotechnology, Universit√† degli Studi di Pavia, Pavia, Italy. (literal)
Titolo
  • Knockout of pgdS and ggt genes improves ?-PGA yield in B. subtilis (literal)
Abstract
  • One of the emerging biopolymers that are currently under active investigation is bacterial poly (?-glutamic acid) (?-PGA). However, before its full industrial exploitation, a substantial increase in microbial productivity is required. ?-PGA obtained from the Bacillus subtilis laboratory strain 168 offers the advantage of a producer characterized by a well defined genetic framework and simple manipulation techniques. In this strain, the knockout of genes for the major ?-PGA degrading enzymes, pgdS and ggt, leads to a considerable improvement in polymer yield, which attains levels analogous to the top wild ?-PGA producer strains. This study highlights the convenience of using the laboratory strain of B. subtilis over wild isolates in designing strain improvement strategies aimed at increasing ?-PGA productivity. (literal)
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