pPKCalpha-mediated effect on in vitro A-beta production in response to gamma secretase inhibitor LY411575 in rat CTXTNA2 astrocytes. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• pPKCalpha-mediated effect on in vitro A-beta production in response to gamma secretase inhibitor LY411575 in rat CTXTNA2 astrocytes. (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Alternative label

• Sozio P, Rapino M, Di Valerio V, Laserra S, Pacella S, Di Stefano A, Cataldi A. (2012)
  pPKCalpha-mediated effect on in vitro A-beta production in response to gamma secretase inhibitor LY411575 in rat CTXTNA2 astrocytes.
  in Journal of Biological Regulators & Homeostatic Agents (Testo stamp.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sozio P, Rapino M, Di Valerio V, Laserra S, Pacella S, Di Stefano A, Cataldi A. (literal)

Pagina inizio

• 245 (literal)

Pagina fine

• 251 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 26 (literal)

Rivista

• Journal of Biological Regulators & Homeostatic Agents (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Scienze del Farmaco, Università G. d'Annunzio, Chieti, Italy; Istituto di Genetica Molecolare del CNR, Unità di Chieti, Università G. d'Annunzio, Chieti, Italy; Dipartimento di Medicina e Scienze dell'Invecchiamento, Università G. d'Annunzio, Via dei Vestini, 31, 66100 Chieti, Italy; Cattedra di Anatomia Umana, Facoltà di Farmacia, Università G. d'Annunzio, Chieti, Italy (literal)

Titolo

• pPKCalpha-mediated effect on in vitro A-beta production in response to gamma secretase inhibitor LY411575 in rat CTXTNA2 astrocytes. (literal)

Abstract

• Alzheimer's Disease implies memory and cognitive impairment due to beta amyloid accumulation, presence of reactive microglia and astrocytes, loss of synapses, neural network dysfunctions and modifications of neuronal signalling. A key role in such events is played by astrocytes, which actively secrete high levels of beta amyloid protein originating from sequential cleavage of APP by alpha, beta and gamma secretases. Since inhibition of such process could represent an important strategy against the occurrence of Alzheimer's Disease, in this paper the role played by pPKC alpha in the in vitro beta amyloid production in response to gamma secretase inhibitor in rat cortical astrocytes is reported. pPKC alpha increased expression seems to be related to decreased beta amyloid production in parallel to increased astrocytes viability and decreased iNOS expression in the presence of 10 microM LY411575. Thus gamma secretase inhibitor, activating pPKC alpha intracellular pathway could be suggested to prevent or reduce downstream toxic events, representing a useful strategy to counteract Alzheimer's disease. (literal)

Prodotto di

• Bersagli molecolari per il controllo della progressione tumorale (ME.P03.012.001) (Modulo)
• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• MONICA RAPINO (Persona)

Insieme di parole chiave

• Keywords of "pPKCalpha-mediated effect on in vitro A-beta production in response to gamma secretase inhibitor LY411575 in rat CTXTNA2 astrocytes." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MONICA RAPINO (Persona)

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Bersagli molecolari per il controllo della progressione tumorale (ME.P03.012.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of Biological Regulators & Homeostatic Agents (Rivista)

Insieme di parole chiave di

• Keywords of "pPKCalpha-mediated effect on in vitro A-beta production in response to gamma secretase inhibitor LY411575 in rat CTXTNA2 astrocytes." (Insieme di parole chiave)