Cisplatin induces changes in the matrix metalloproteinases and their inhibitors in the developing rat cerebellum. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Cisplatin induces changes in the matrix metalloproteinases and their inhibitors in the developing rat cerebellum. (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.brainres.2012.09.025 (literal)

Alternative label

• Piccolini VM, Avella D, Bottone MG, Bottiroli G, Bernocchi G. (2012)
  Cisplatin induces changes in the matrix metalloproteinases and their inhibitors in the developing rat cerebellum.
  in Brain research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Piccolini VM, Avella D, Bottone MG, Bottiroli G, Bernocchi G. (literal)

Pagina inizio

• 15 (literal)

Pagina fine

• 28 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S0006899312015077 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 1484 (literal)

Rivista

• Brain research (Rivista)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Biologia e Biotecnologie ''Lazzaro Spallanzani'', Universita di Pavia, Via Ferrata 9, Pavia 27100, Italy; Istituto di Genetica Molecolare del CNR, Sezione di Istochimica e Citometria, Via Ferrata 9, 27100 Pavia, Italy (literal)

Titolo

• Cisplatin induces changes in the matrix metalloproteinases and their inhibitors in the developing rat cerebellum. (literal)

Abstract

• The role of matrix metalloproteinases (MMP-3 and MMP-9), tissue inhibitor of MMP (TIMP-2), and GAP-43 (growth-associated-protein) in neocerebellar vermis lobules during postnatal histogenesis was studied after challenge with cisplatin (cisPt). CisPt is one of the most effective and widely used cytotoxic agents in the treatment of a variety of malignancies, in both children and adult patients. A single injection of cisPt to 10-day-old rats altered the spatiotemporal MMP/TIMP expression balance and provoked a decrease in GAP43 immunoreactivity. The imbalance appeared one day (PD11) after cisPt injection, producing disorder of cerebellum histogenesis processes in which MMPs might be involved, i.e. genesis of granule cells, Purkinje cell differentiation and synaptogenesis. Following the early injury, a simultaneous increase in MMP and TIMP expression in the ML was noticed at PD17, likely initiating recovery of Purkinje cell dendrite growth and remodelling processes. However, disturbances at the beginning of recovery phase had emerged, probably due to the down-regulation of GAP-43 after cisPt treatment. The data provide further support for the usefulness of cisPt as a tool for the study of morphological and functional changes in the CNS during postnatal development. (literal)

Prodotto di

• Sviluppo di nuove tecniche e metodologie ottiche per biologia di base e applicazioni biomediche (ME.P04.004.002) (Modulo)
• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• GIOVANNI BOTTIROLI (Persona)

Insieme di parole chiave

• Keywords of "Cisplatin induces changes in the matrix metalloproteinases and their inhibitors in the developing rat cerebellum." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Sviluppo di nuove tecniche e metodologie ottiche per biologia di base e applicazioni biomediche (ME.P04.004.002) (Modulo)

Autore CNR di

• GIOVANNI BOTTIROLI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Brain research (Rivista)

Insieme di parole chiave di

• Keywords of "Cisplatin induces changes in the matrix metalloproteinases and their inhibitors in the developing rat cerebellum." (Insieme di parole chiave)