Tissue transglutaminase is the target in both rodent and primate tissues for celiac disease-specific autoantibodies (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Tissue transglutaminase is the target in both rodent and primate tissues for celiac disease-specific autoantibodies (Articolo in rivista) (literal)

Anno

• 2000-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1097/00005176-200011000-0001 (literal)

Alternative label

• Korponay-Szabó, I.R.ad, Sulkanen, S.a, Halttunen, T.a, Maurano, F.e, Rossi, M.e, Mazzarella, G.e, Laurila, K.a, Troncone, R.f, Mäki, M.abcg (2000)
  Tissue transglutaminase is the target in both rodent and primate tissues for celiac disease-specific autoantibodies
  in Journal of pediatric gastroenterology and nutrition
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Korponay-Szabó, I.R.ad, Sulkanen, S.a, Halttunen, T.a, Maurano, F.e, Rossi, M.e, Mazzarella, G.e, Laurila, K.a, Troncone, R.f, Mäki, M.abcg (literal)

Pagina inizio

• 520 (literal)

Pagina fine

• 527 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 31 (literal)

Rivista

• Journal of pediatric gastroenterology and nutrition (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a Institute of Medical Technology, University of Tampere, Tampere, Finland b Department of Pediatrics, University of Tampere, Tampere, Finland c Medical School, University of Tampere, Tampere, Finland d Heim Pál Children's Hospital, Budapest, Hungary e Institute of Food Science and Technology, Consiglio Nazionale delle Ricerche, Avellino, Italy f Department of Pediatrics, European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Naples, Italy g Coeliac Disease Study Group, Institute of Medical Technology, University of Tampere, P.O. Box 607, FIN-33101 Tampere, Finland (literal)

Titolo

• Tissue transglutaminase is the target in both rodent and primate tissues for celiac disease-specific autoantibodies (literal)

Abstract

• Background: Endomysial antibodies have recently been shown to react with tissue transglutaminase. This study was undertaken to investigate whether the tissue distribution of transglutaminase is also compatible with reticulin, jejunal, and fibroblast autoantibody binding patterns. Methods: Sera from patients with and without celiac disease, monoclonal tissue transglutaminase antibodies, and sera from mice parenterally immunized against commercially available tissue transglutaminase, transglutaminase complexed with gliadin, or gliadin were used in indirect immunofluorescence and double-staining studies using both rodent and primate tissues as substrates. Also, antibody competition, affinity chromatography, and potassium thiocyanate extraction studies were undertaken. Results: Tissue transglutaminase antibody binding patterns were identical with the extracellular binding patterns seen with celiac patient sera. Human umbilical cord-derived fibroblasts exhibited both cytoplasmic and extracellular matrix staining. Double staining with patients' sera and tissue transglutaminase antibodies showed complete overlapping. Tissue transglutaminase effectively absorbed reticulin-endomysial antibodies from celiac sera, and patients' sera blocked the staining of the monoclonal tissue transglutaminase antibodies. Potassium thiocyanate extraction abolished the staining patterns, but they were elicited again after readdition of tissue transglutaminase. Conclusions: Reticulin, endomysial, and jejunal antibodies detect transglutaminase in both rodent and primate tissues, indicating that these tissue autoantibodies are identical. (literal)

Prodotto di

• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)
• Institute of food sciences (ISA) (Istituto)

Autore CNR

• GIUSEPPE MAZZARELLA (Unità di personale interno)
• FRANCESCO MAURANO (Persona)
• MAURO ROSSI (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Tissue transglutaminase is the target in both rodent and primate tissues for celiac disease-specific autoantibodies" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of food sciences (ISA) (Istituto)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)

Autore CNR di

• MAURO ROSSI (Unità di personale interno)
• GIUSEPPE MAZZARELLA (Unità di personale interno)
• FRANCESCO MAURANO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of pediatric gastroenterology and nutrition (Rivista)

Insieme di parole chiave di

• Keywords of "Tissue transglutaminase is the target in both rodent and primate tissues for celiac disease-specific autoantibodies" (Insieme di parole chiave)