Cluster-Driven Dynamical Arrest in Concentrated Lysozyme Solutions (Articolo in rivista)

Type
Label
  • Cluster-Driven Dynamical Arrest in Concentrated Lysozyme Solutions (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/jp112180p (literal)
Alternative label
  • Frédéric Cardinaux (1); Emanuela Zaccarelli (2; Anna Stradner (3); Saskia Bucciarelli (3); Bela Farago (4) Stefan U. Egelhaaf (5); Francesco Sciortino (2); Peter Schurtenberger (6) (2011)
    Cluster-Driven Dynamical Arrest in Concentrated Lysozyme Solutions
    in The journal of physical chemistry. B
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Frédéric Cardinaux (1); Emanuela Zaccarelli (2; Anna Stradner (3); Saskia Bucciarelli (3); Bela Farago (4) Stefan U. Egelhaaf (5); Francesco Sciortino (2); Peter Schurtenberger (6) (literal)
Pagina inizio
  • 7227 (literal)
Pagina fine
  • 7237 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Special Issue: Clusters in Complex Fluids (literal)
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  • http://pubs.acs.org/doi/abs/10.1021/jp112180p (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 115 (literal)
Rivista
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  • 22 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Department of Physics, University of Fribourg, Fribourg, Switzerland 2 Dipartimento di Fisica and CNR-ISC, Università di Roma La Sapienza, Roma, Italy 3 Adolphe Merkle Institute, University of Fribourg, Marly, Switzerland 4 Institute Laue-Langevin, Grenoble, France 5 Condensed Matter Physics Laboratory, Heinrich-Heine University, Duesseldorf, Germany 6 Division of Physical Chemistry, Lund University, Lund, Sweden (literal)
Titolo
  • Cluster-Driven Dynamical Arrest in Concentrated Lysozyme Solutions (literal)
Abstract
  • We present a detailed experimental and numerical study of the structural and dynamical properties of salt-free lysozyme solutions. In particular, by combining small-angle X-ray scattering (SAXS) data with neutron spin echo (NSE) and rheology experiments, we are able to identify that an arrest transition takes place at intermediate densities, driven by the slowing down of the cluster motion. Using an effective pair potential among proteins, based on the combination of short-range attraction and long-range repulsion, we account remarkably well for the peculiar volume fraction dependence of the effective structure factor measured by SAXS. We show that a transition from a monomer to a cluster-dominated fluid happens at volume fractions larger than phi greater than or similar to 0.05 where the close agreement between NSE measurements and Brownian dynamics simulations confirms the transient nature of the clusters. Clusters even stay transient above the geometric percolation found in simulation at phi > 0.15, though NSE reveals a cluster lifetime that becomes increasingly large and indicates a divergence of the diffusivity at phi greater than or similar to 0.26. Macroscopic measurements of the viscosity confirm this transition where the long-lived-nature of the clusters is at the origin of the simultaneous dynamical arrest at all length scales. (literal)
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