http://www.cnr.it/ontology/cnr/individuo/prodotto/ID199496
Nanovectors for drug delivery: long-lived pore dynamics for swelling liposomes (Articolo in rivista)
- Type
- Label
- Nanovectors for drug delivery: long-lived pore dynamics for swelling liposomes (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.mechrescom.2010.11.002 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
- PUMA_ID: cnr.isti/cnr.isti/2011-A0-008 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.sciencedirect.com/science/article/pii/S0093641310001618# (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Scopu (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- ISTI-CNR, Signal and Visual Images Laboratory, via Moruzzi 1, I-56124 Pisa, Italy (literal)
- Titolo
- Nanovectors for drug delivery: long-lived pore dynamics for swelling liposomes (literal)
- Abstract
- A liposome is a spherical, bilayer vesicle separating the interior volume containing an aqueous solution, from an exterior suspension. A fundamental practical application provides the liposome used as vehicles for drug delivery. In this case, liposomes are designed to contain a specific drug or a gene needed to fight the disease. If a vesicle containing high internal solute concentration is placed inside a dilute solution, the osmotic flux of solvent into the interior can lead to its rupture or a formation of pores. Such pores can be long-lived pores or short-lived pores suddenly closing after their formations. Long-lived pores lead to a well controlled drug delivery. In this paper, we show that the existence of long-lived pores is completely conditioned only by the pore dynamics, and that the long-lived pore dynamics is highly stable because sustained by a limit cycle. Moreover, we calculate analytically the frequency of a long-lived pore making use of the He's variational method. (literal)
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- Autore CNR
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