Tetra-2,3-pyrazinoporphyrazines with externally appended pyridine rings. 10. A water-soluble bimetallic (ZnII/PtII) porphyrazine hexacation as potential plurimodal agent for cancer therapy: Exploring the behavior as ligand of telomeric DNA G-quadruplex st (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Tetra-2,3-pyrazinoporphyrazines with externally appended pyridine rings. 10. A water-soluble bimetallic (ZnII/PtII) porphyrazine hexacation as potential plurimodal agent for cancer therapy: Exploring the behavior as ligand of telomeric DNA G-quadruplex st (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/ic200514z (literal)

Alternative label

• Manet, I., Manoli, F., Donzello, M.P., Ercolani, C., Vittori, D., Cellai, L., Masi, A., Monti, S. (2011)
  Tetra-2,3-pyrazinoporphyrazines with externally appended pyridine rings. 10. A water-soluble bimetallic (ZnII/PtII) porphyrazine hexacation as potential plurimodal agent for cancer therapy: Exploring the behavior as ligand of telomeric DNA G-quadruplex st
  in Inorganic chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Manet, I., Manoli, F., Donzello, M.P., Ercolani, C., Vittori, D., Cellai, L., Masi, A., Monti, S. (literal)

Pagina inizio

• 7403 (literal)

Pagina fine

• 7411 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 50 (literal)

Rivista

• Inorganic chemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Manet, I., Manoli, F., Masi, A., Monti, S.: ISOF-CNR (literal)

Titolo

• Tetra-2,3-pyrazinoporphyrazines with externally appended pyridine rings. 10. A water-soluble bimetallic (ZnII/PtII) porphyrazine hexacation as potential plurimodal agent for cancer therapy: Exploring the behavior as ligand of telomeric DNA G-quadruplex st (literal)

Abstract

• The behavior of a bimetallic water-soluble (Zn(II)/Pt(II)) porphyrazine hexacation as ligand of G-quadruplex (G4) structures adopted by a human telomeric DNA sequence has been examined with different spectroscopic techniques. In K(+) rich solution the hexacationic Zn(II) porphyrazine ligand bearing a peripheral cis-platin-like functionality changes the G-quadruplex conformational equilibrium of the human telomeric sequence 5'-d[AGGG(TTAGGG)(3)]-3' and drives it exclusively toward a very stable parallel G4 form in the complex with 2:1 stoichiometry. An increase of the melting temperature of more than 20 degrees C is observed in this complex compared to the G4 alone. On the contrary ligand binding to G-quadruplex of the same telomeric sequence in Na(+) rich solution neither markedly influences the predominant basket conformation nor confers increased thermal stability to the G4 structure. (literal)

Prodotto di

• Studio delle interazioni legando-recettore in sistemi modello mediante metodi spettroscopici e fotofisici (LEGARE) (PM.P06.005.002) (Modulo)
• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Institute of Crystallography (IC) (Istituto)
• Studi strutturali e funzionali di acidi nucleici e sistemi nucleoproteici (PM.P01.023.006) (Modulo)

Autore CNR

• Claudio ERCOLANI (Persona)
• SANDRA MONTI (Persona)
• ANNALISA MASI (Persona)
• FRANCESCO MANOLI (Persona)
• ILSE GERT MANET (Unità di personale interno)
• LUCIANO CELLAI (Unità di personale esterno)

Incoming links:

Prodotto

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Institute of Crystallography (IC) (Istituto)
• Studi strutturali e funzionali di acidi nucleici e sistemi nucleoproteici (PM.P01.023.006) (Modulo)
• Studio delle interazioni legando-recettore in sistemi modello mediante metodi spettroscopici e fotofisici (LEGARE) (PM.P06.005.002) (Modulo)

Autore CNR di

• ILSE GERT MANET (Unità di personale interno)
• FRANCESCO MANOLI (Persona)
• SANDRA MONTI (Persona)
• ANNALISA MASI (Persona)
• LUCIANO CELLAI (Unità di personale esterno)
• Claudio ERCOLANI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Inorganic chemistry (Rivista)