Searching for Predictive Blood Biomarkers: Misfolded p53 In Mild Cognitive Impairment. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Searching for Predictive Blood Biomarkers: Misfolded p53 In Mild Cognitive Impairment. (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.2174/1567205011209041191 (literal)

Alternative label

• Stanga S, Lanni C, Sinforiani E, Mazzini, G, Racchi M. (2012)
  Searching for Predictive Blood Biomarkers: Misfolded p53 In Mild Cognitive Impairment.
  in Current Alzheimer research (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Stanga S, Lanni C, Sinforiani E, Mazzini, G, Racchi M. (literal)

Pagina inizio

• 1191 (literal)

Pagina fine

• 1197 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.eurekaselect.com/105023/article (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 9 (literal)

Rivista

• Current Alzheimer research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 10 (literal)

Note

• ISI Web of Science (WOS) (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Univ Pavia, Dept Drug Sci, Pharmacol Unit, Ctr Excellence Appl Biol, I-27100 Pavia, Italy; Natl Inst Neurol Fdn, Alzheimers Dis Assessment Unit, Neuropsychol Lab, IRCCS C Mondino, Pavia, Italy; Univ Pavia, IGM CNR, I-27100 Pavia, Italy (literal)

Titolo

• Searching for Predictive Blood Biomarkers: Misfolded p53 In Mild Cognitive Impairment. (literal)

Abstract

• Abstract: The identification and validation of biomarkers for preclinical patients with mild cognitive impairment (MCI) at-risk for Alzheimer's disease (AD) development is increasingly important. We used the cytofluorimetric analysis of unfolded p53 to determine the prognostic ability of the protein as predictive signature from MCI to AD in a longitudinal study of a population of presymptomatic patients with the clinical diagnosis of MCI. Venous blood samples from 24 healthy subjects, 28 MCI and 15 AD were analyzed with the cytofluorimetric method for unfolded p53 protein detection. Twenty-four MCI patients had clinical follow-up subsequent to the analysis for unfolded p53. Elevated levels of the conformationally altered protein were able to discriminate both MCI and AD patients comparing with healthy subjects. Longitudinal follow-up revealed that 7/24 MCI patients progressed to AD. All converters (100%) were predicted by elevated levels of unfolded p53, with a positive predictive value of 87.5%. These data support and extend our previous observation that the cytofluorimetric approach for unfolded p53 protein was able to discriminate AD patients from healthy subjects and to predict the progression from MCI to AD in presymptomatic patients before clinical diagnosis for AD was evident. (literal)

Prodotto di

• Sviluppo di nuove tecniche e metodologie ottiche per biologia di base e applicazioni biomediche (ME.P04.004.002) (Modulo)
• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• GIULIANO MAZZINI (Persona)

Insieme di parole chiave

• Keywords of "Searching for Predictive Blood Biomarkers: Misfolded p53 In Mild Cognitive Impairment." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Sviluppo di nuove tecniche e metodologie ottiche per biologia di base e applicazioni biomediche (ME.P04.004.002) (Modulo)

Autore CNR di

• GIULIANO MAZZINI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Current Alzheimer research (Rivista)

Insieme di parole chiave di

• Keywords of "Searching for Predictive Blood Biomarkers: Misfolded p53 In Mild Cognitive Impairment." (Insieme di parole chiave)