http://www.cnr.it/ontology/cnr/individuo/prodotto/ID199021
Lipid-induced insulin resistance is not mediated by impaired transcapillary transport of insulin and glucose in humans (Articolo in rivista)
- Type
- Label
- Lipid-induced insulin resistance is not mediated by impaired transcapillary transport of insulin and glucose in humans (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.2337/db12-0108 (literal)
- Alternative label
Szendrödi, J.;Frossard, M.;Klein, N.;Biegelmayer, C.;Wagner, O.;Pacini, G.;Decker, J.;Nowotny, P.;Müller, M.;Roden, M. (2012)
Lipid-induced insulin resistance is not mediated by impaired transcapillary transport of insulin and glucose in humans
in Diabetes (N.Y.N.Y.)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Szendrödi, J.;Frossard, M.;Klein, N.;Biegelmayer, C.;Wagner, O.;Pacini, G.;Decker, J.;Nowotny, P.;Müller, M.;Roden, M. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.ncbi.nlm.nih.gov/pubmed/22891212 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Scopu (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1, 10: Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Düsseldorf, Germany and Department of Metabolic Diseases, Heinrich Heine University, Düsseldorf, Germany /
7, 8: Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Düsseldorf, Germany /
2, 4: Department of Clinical Pharmacology, Medical University of Vienna,
Vienna, Austria and Department of Laboratory Medicine, Medical University
of Vienna, Vienna, Austria /
3, 9: Department of Clinical Pharmacology, Medical University of Vienna,
Vienna, Austria /
5: Department of Laboratory Medicine, Medical University
of Vienna, Vienna, Austria /
6: Metabolic Unit, ISIB-CNR, Corso
Stati Uniti, Padova, Italy. (literal)
- Titolo
- Lipid-induced insulin resistance is not mediated by impaired transcapillary transport of insulin and glucose in humans (literal)
- Abstract
- Increased lipid availability reduces insulin-stimulated glucose
disposal in skeletal muscle, which is generally explained by fatty
acid-mediated inhibition of insulin signaling. It remains unclear
whether lipids also impair transcapillary transport of insulin and
glucose, which could become rate controlling for glucose disposal.
We hypothesized that lipid-induced insulin resistance is
induced by inhibiting myocellular glucose uptake and not by interfering
with the delivery of insulin or glucose. We measured
changes in interstitial glucose and insulin in skeletal muscle of
healthy volunteers during intravenous administration of triglycerides
plus heparin or glycerol during physiologic and supraphysiologic
hyperinsulinemia, by combining microdialysis with oral
glucose tolerance tests and euglycemic-hyperinsulinemic clamps.
Lipid infusion reduced insulin-stimulated glucose disposal by
;70% (P , 0.05) during clamps and dynamic insulin sensitivity
by ;12% (P , 0.05) during oral glucose loading. Dialysate insulin
and glucose levels were unchanged or even transiently higher
(P , 0.05) during lipid than during glycerol infusion, whereas
regional blood flow remained unchanged. These results demonstrate
that short-term elevation of free fatty acids (FFAs) induces
insulin resistance, which in skeletal muscle occurs primarily at
the cellular level, without impairment of local perfusion or transcapillary
transport of insulin and glucose. Thus, vascular effects
of FFAs are not rate controlling for muscle insulin-stimulated
glucose disposal. (literal)
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