Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/emboj.2012.132 (literal)

Alternative label

• Suram A, Kaplunov J, Patel PL, Ruan H, Cerutti A, Boccardi V, Fumagalli M, Di Micco R, Mirani N, Gurung RL, Hande MP, d'Adda di Fagagna F, Herbig U. (2012)
  Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions.
  in EMBO journal (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Suram A, Kaplunov J, Patel PL, Ruan H, Cerutti A, Boccardi V, Fumagalli M, Di Micco R, Mirani N, Gurung RL, Hande MP, d'Adda di Fagagna F, Herbig U. (literal)

Pagina inizio

• 2839 (literal)

Pagina fine

• 2851 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.nature.com/emboj/journal/v31/n13/full/emboj2012132a.html (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 31 (literal)

Rivista

• EMBO journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 13 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 13 (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• New Jersey Medical School-University Hospital Cancer Center, UMDNJ-New Jersey Medical School, Newark, NJ, USA; Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, Newark, NJ, USA; IFOM Foundation--FIRC Institute of Molecular Oncology Foundation, Milan, Italy; Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, Newark, NJ, USA; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy (literal)

Titolo

• Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. (literal)

Abstract

• In normal human somatic cells, telomere dysfunction causes cellular senescence, a stable proliferative arrest with tumour suppressing properties. Whether telomere dysfunction-induced senescence (TDIS) suppresses cancer growth in humans, however, is unknown. Here, we demonstrate that multiple and distinct human cancer precursor lesions, but not corresponding malignant cancers, are comprised of cells that display hallmarks of TDIS. Furthermore, we demonstrate that oncogenic signalling, frequently associated with initiating cancer growth in humans, dramatically affected telomere structure and function by causing telomeric replication stress, rapid and stochastic telomere attrition, and consequently telomere dysfunction in cells that lack hTERT activity. DNA replication stress induced by drugs also resulted in telomere dysfunction and cellular senescence in normal human cells, demonstrating that telomeric repeats indeed are hypersensitive to DNA replication stress. Our data reveal that TDIS, accelerated by oncogene-induced DNA replication stress, is a biological response of cells in human cancer precursor lesions and provide strong evidence that TDIS is a critical tumour suppressing mechanism in humans. (literal)

Prodotto di

• Studio della regolazione post-trascrizionale dell'espressione genica in risposta a stress. Fattori che controllano lo splicing dei mRNA in cellule normali e nei tumori. (SV.P13.001.001) (Modulo)
• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• FABRIZIO D'ADDA DI FAGAGNA (Persona)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Studio della regolazione post-trascrizionale dell'espressione genica in risposta a stress. Fattori che controllano lo splicing dei mRNA in cellule normali e nei tumori. (SV.P13.001.001) (Modulo)

Autore CNR di

• FABRIZIO D'ADDA DI FAGAGNA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• EMBO journal (Rivista)