http://www.cnr.it/ontology/cnr/individuo/prodotto/ID198605
Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer. (Articolo in rivista)
- Type
- Label
- Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer. (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1038/nrc3344 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Sulli G, Di Micco R, d'Adda di Fagagna F. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.nature.com/nrc/journal/v12/n10/full/nrc3344.html (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Note
- ISI Web of Science (WOS) (literal)
- Scopu (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Gabriele Sulli, Raffaella Di Micco and Fabrizio d'Adda di Fagagna are at IFOM Foundation - FIRC Institute of Molecular Oncology Foundation, Milan 20139, Italy.
Gabriele Sulli's present address is at The Salk Institute for Biological Studies, California 92037, USA.
Raffaella Di Micco's present address is at The New York University School of Medicine, Department of Pathology, New York 10016, USA.
Fabrizio d'Adda di Fagagna is at Istituto di Genetica Molecolare - Consiglio Nazionale delle Ricerche, Via Abbiategrasso 207, 27100 Pavia, Italy. (literal)
- Titolo
- Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer. (literal)
- Abstract
- The generation of DNA lesions and the resulting activation of DNA damage response (DDR) pathways are both affected by the chromatin status at the site of damaged DNA. In turn, DDR activation affects the chromatin at both the damaged site and across the whole genome. Cellular senescence and cancer are associated with the engagement of the DDR pathways and with profound chromatin changes. In this Opinion article, we discuss the interplay between chromatin and DDR factors in the context of cellular senescence that is induced by oncogenes and in cancer. (literal)
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- Autore CNR
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