Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/ncb2466 (literal)

Alternative label

• Fumagalli M, Rossiello F, Clerici M, Barozzi S, Cittaro D, Kaplunov JM, Bucci G, Dobreva M, Matti V, Beausejour CM, Herbig U, Longhese MP, d'Adda di Fagagna F. (2012)
  Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.
  in Nature cell biology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Fumagalli M, Rossiello F, Clerici M, Barozzi S, Cittaro D, Kaplunov JM, Bucci G, Dobreva M, Matti V, Beausejour CM, Herbig U, Longhese MP, d'Adda di Fagagna F. (literal)

Pagina inizio

• 355 (literal)

Pagina fine

• 365 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.nature.com/ncb/journal/v14/n4/full/ncb2466.html (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 14 (literal)

Rivista

• Nature cell biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IFOM Foundation--FIRC Institute of Molecular Oncology Foundation, Milan 20139, Italy Marzia Fumagalli, Francesca Rossiello, Miryana Dobreva, Valentina Matti & Fabrizio d'Adda di Fagagna Department of Biotechnology and Biosciences, University of Milano Bicocca, Milan 20126, Italy Michela Clerici & Maria Pia Longhese Department of Experimental Oncology, European Institute of Oncology, Milan 20139, Italy Sara Barozzi Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia, at the IFOM-IEO Campus, Milan 20139, Italy Davide Cittaro & Gabriele Bucci Cogentech, Consortium for Genomic Technologies, Milan 20139, Italy Davide Cittaro & Gabriele Bucci Department of Microbiology and Molecular Genetics--NJMS-UH Cancer Center, Newark, New Jersey 07103, USA Jessica M. Kaplunov & Utz Herbig Department of Pharmacology, Université de Montréal & Centre Hospitalier Universitaire Sainte-Justine, Montréal, Quebec H3S 2G5, Canada Christian M. Beausejour Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia 27100, Italy Fabrizio d'Adda di Fagagna (literal)

Titolo

• Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. (literal)

Abstract

• The DNA-damage response (DDR) arrests cell-cycle progression until damage is removed. DNA-damage-induced cellular senescence is associated with persistent DDR. The molecular bases that distinguish transient from persistent DDR are unknown. Here we show that a large fraction of exogenously induced persistent DDR markers is associated with telomeric DNA in cultured cells and mammalian tissues. In yeast, a chromosomal DNA double-strand break next to a telomeric sequence resists repair and impairs DNA ligase 4 recruitment. In mammalian cells, ectopic localization of telomeric factor TRF2 next to a double-strand break induces persistent DNA damage and DDR. Linear, but not circular, telomeric DNA or scrambled DNA induces a prolonged checkpoint in normal cells. In terminally differentiated tissues of old primates, DDR markers accumulate at telomeres that are not critically short. We propose that linear genomes are not uniformly reparable and that telomeric DNA tracts, if damaged, are irreparable and trigger persistent DDR and cellular senescence. (literal)

Prodotto di

• Institute of molecular genetics (IGM) (Istituto)
• Studio della regolazione post-trascrizionale dell'espressione genica in risposta a stress. Fattori che controllano lo splicing dei mRNA in cellule normali e nei tumori. (SV.P13.001.001) (Modulo)

Autore CNR

• FABRIZIO D'ADDA DI FAGAGNA (Persona)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Studio della regolazione post-trascrizionale dell'espressione genica in risposta a stress. Fattori che controllano lo splicing dei mRNA in cellule normali e nei tumori. (SV.P13.001.001) (Modulo)

Autore CNR di

• FABRIZIO D'ADDA DI FAGAGNA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nature cell biology (Rivista)