Modulating DNA translocation by a controlled deformation of a PDMS nanochannel device (Articolo in rivista)

Type
Label
  • Modulating DNA translocation by a controlled deformation of a PDMS nanochannel device (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/srep00791 (literal)
Alternative label
  • Paola Fanzio1, Chiara Manneschi1*, Elena Angeli1, Valentina Mussi1, Giuseppe Firpo1, Luca Ceseracciu2, Luca Repetto1 & Ugo Valbusa1 (2012)
    Modulating DNA translocation by a controlled deformation of a PDMS nanochannel device
    in Scientific reports (Nature Publishing Group)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Paola Fanzio1, Chiara Manneschi1*, Elena Angeli1, Valentina Mussi1, Giuseppe Firpo1, Luca Ceseracciu2, Luca Repetto1 & Ugo Valbusa1 (literal)
Pagina inizio
  • 791 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 2 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Nanomed Labs, Dipartimento di Fisica, Universita` di Genova, via Dodecaneso 33 Genova, 16146, Italy, 2Nanophysics, Istituto Italiano di Tecnologia (IIT), via Morego, 30 Genova, 16163, Italy. (literal)
Titolo
  • Modulating DNA translocation by a controlled deformation of a PDMS nanochannel device (literal)
Abstract
  • Several strategies have been developed for the control of DNA translocation in nanopores and nanochannels. However, the possibility to reduce the molecule speed is still challenging for applications in the field of single molecule analysis, such as ultra-rapid sequencing. This paper demonstrates the possibility to alter theDNAtranslocation process through an elastomeric nanochannel device by dynamically changing its cross section. More in detail, nanochannel deformation is induced by a macroscopic mechanical compression of the polymeric device. This nanochannel squeezing allows slowing down the DNA molecule passage inside it. This simple and low cost method is based on the exploitation of the elastomeric nature of the device, can be coupled with different sensing techniques, is applicable in many research fields, such as DNA detection and manipulation, and is promising for further development in sequencing technology. (literal)
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