Poly (ADP-Ribosylation) and Neoplastic Transformation: Effect of PARP Inhibitors (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Poly (ADP-Ribosylation) and Neoplastic Transformation: Effect of PARP Inhibitors (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Alternative label

• Dona' F, Chiodi I, Belgiovine C, Raineri T, Ricotti R, Mondello C and Scovassi AI (2013)
  Poly (ADP-Ribosylation) and Neoplastic Transformation: Effect of PARP Inhibitors
  in Current pharmaceutical biotechnology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Dona' F, Chiodi I, Belgiovine C, Raineri T, Ricotti R, Mondello C and Scovassi AI (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• in press (literal)

Rivista

• Current pharmaceutical biotechnology (Rivista)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Genetica Molecolare, Pavia (literal)

Titolo

• Poly (ADP-Ribosylation) and Neoplastic Transformation: Effect of PARP Inhibitors (literal)

Abstract

• Poly (ADP-ribose) polymerases (PARPs) and poly (ADP-ribosylation) play essential roles in several biological processes, among which neoplastic transformation and telomere maintenance. In this paper, we review the poly(ADP- ribosylation) process together with the highly appealing use of PARP inhibitors for the treatment of cancer. In addition, we report our results concerning poly (ADP-ribosylation) in a cellular model system for neoplastic transformation devel- oped in our laboratory. Here we show that PARP-1 and PARP-2 expression increases during neoplastic transformation, together with the basal levels of poly (ADP-ribosylation). Furthermore, we demonstrate a greater effect of the PARP in- hibitor 3-aminobenzamide (3AB) on cellular viability in neoplastically transformed cells compared to normal fibroblasts and we show that prolonged 3AB administration to tumorigenic cells causes a decrease in telomere length. Taken to- gether, our data support an active involvement of poly (ADP-ribosylation) in neoplastic transformation and telomere length maintenance and confirm the relevant role of poly (ADP-ribosylation) inhibition for the treatment of cancer. (literal)

Prodotto di

• Studio di pathway coinvolti nella progressione tumorale (ME.P05.005.002) (Modulo)
• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• Francesca Dona' (Persona)
• CHIARA MONDELLO (Unità di personale interno)
• ANNA SCOVASSI (Unità di personale interno)
• ROBERTA RICOTTI (Persona)
• Cristina Belgiovine (Persona)
• ILARIA CHIODI (Persona)

Insieme di parole chiave

• Parole chiave di "Poly (ADP-Ribosylation) and Neoplastic Transformation: Effect of PARP Inhibitors" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Studio di pathway coinvolti nella progressione tumorale (ME.P05.005.002) (Modulo)

Autore CNR di

• ANNA SCOVASSI (Unità di personale interno)
• ROBERTA RICOTTI (Persona)
• CHIARA MONDELLO (Unità di personale interno)
• Cristina Belgiovine (Persona)
• ILARIA CHIODI (Persona)
• Francesca Dona' (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Current pharmaceutical biotechnology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Poly (ADP-Ribosylation) and Neoplastic Transformation: Effect of PARP Inhibitors" (Insieme di parole chiave)