Allergens in allergy diagnosis: a glimpse at emerging new concepts and methodologies. (Articolo in rivista)

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  • Allergens in allergy diagnosis: a glimpse at emerging new concepts and methodologies. (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Ivana Giangrieco1,2, Chiara Rafaiani2, Marina Liso2, Paola Palazzo2, Debora Pomponi2, Lisa Tuppo1,2, Roberta Crescenzo1,2, Maurizio Tamburrini1, Adriano Mari2, Maria Antonietta Ciardiello1 (2012)
    Allergens in allergy diagnosis: a glimpse at emerging new concepts and methodologies.
    in Translational medicine @ UniSa
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ivana Giangrieco1,2, Chiara Rafaiani2, Marina Liso2, Paola Palazzo2, Debora Pomponi2, Lisa Tuppo1,2, Roberta Crescenzo1,2, Maurizio Tamburrini1, Adriano Mari2, Maria Antonietta Ciardiello1 (literal)
Pagina inizio
  • 27 (literal)
Pagina fine
  • 33 (literal)
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  • http://www.unisa.it/uploads/7638/03.pdf (literal)
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  • 4 (literal)
Rivista
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  • 7 (literal)
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  • 3 (literal)
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  • 1 Institute of Protein Biochemistry, CNR, Naples, Italy 2 Center for Molecular Allergology, IDI-IRCCS, Rome, Italy E-mail: i.giangrieco@ibp.cnr.it; ma.ciardiello@ibp.cnr.it (literal)
Titolo
  • Allergens in allergy diagnosis: a glimpse at emerging new concepts and methodologies. (literal)
Abstract
  • Allergic diseases are important concern of public health. A reliable diagnosis is of utmost importance for the management of allergic patients both when immunotherapy is planned and when the treatment is essentially based on the avoidance of the allergy source. However, the available diagnostic systems sometimes fail to detect specific IgE antibodies thus impairing the correct diagnosis. The traditional test systems are generally based on the use of protein extracts derived from the allergenic sources whose composition is very variable and cannot be standardized. The development of a new methodology combining the so-called allergenic molecule-based diagnosis with the multiplex microarray technology and allowing the analysis of multiple purified allergens in a single test represents an important improvement in allergy diagnosis. In addition, the biochemical and immunological characterisation of individual allergens has provided new insights into the understanding of allergen-IgE recognition that could be exploited for further improvements of allergy diagnostic tests. (literal)
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