http://www.cnr.it/ontology/cnr/individuo/prodotto/ID198231
Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria. (Articolo in rivista)
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- Label
- Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria. (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.3389/fonc.2012.00133 (literal)
- Alternative label
Chiodi I, Mondello C (2012)
Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria.
in Frontiers in oncology
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Chiodi I, Mondello C (literal)
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- Rivista
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto di Genetica Molecolare, Pavia (literal)
- Titolo
- Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria. (literal)
- Abstract
- Telomerase canonical activity at telomeres prevents telomere shortening, allowing chro- mosome stability and cellular proliferation. To perform this task, the catalytic subunit (telomerase reverse transcriptase, TERT) of the enzyme works as a reverse transcriptase together with the telomerase RNA component (TERC), adding telomeric repeats to DNA molecule ends. Growing evidence indicates that, besides the telomeric-DNA synthesis activity, TERT has additional functions in tumor development and is involved in many differ- ent biological processes, among which cellular proliferation, gene expression regulation, and mitochondrial functionality. TERT has been shown to act independently of TERC in the Wnt-?-catenin signaling pathway, regulating the expression of Wnt target genes, which play a role in development and tumorigenesis. Moreover, TERT RNA-dependent RNA poly- merase activity has been found, leading to the genesis of double-stranded RNAs that act as precursor of silencing RNAs. In mitochondria, a TERT TERC-independent reverse transcriptase activity has been described that could play a role in the protection of mito- chondrial integrity. In this review, we will discuss some of the extra-telomeric functions of telomerase. (literal)
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