Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria. (Articolo in rivista)

Type
Label
  • Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria. (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.3389/fonc.2012.00133 (literal)
Alternative label
  • Chiodi I, Mondello C (2012)
    Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria.
    in Frontiers in oncology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Chiodi I, Mondello C (literal)
Pagina inizio
  • 133 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 2 (literal)
Rivista
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Genetica Molecolare, Pavia (literal)
Titolo
  • Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria. (literal)
Abstract
  • Telomerase canonical activity at telomeres prevents telomere shortening, allowing chro- mosome stability and cellular proliferation. To perform this task, the catalytic subunit (telomerase reverse transcriptase, TERT) of the enzyme works as a reverse transcriptase together with the telomerase RNA component (TERC), adding telomeric repeats to DNA molecule ends. Growing evidence indicates that, besides the telomeric-DNA synthesis activity, TERT has additional functions in tumor development and is involved in many differ- ent biological processes, among which cellular proliferation, gene expression regulation, and mitochondrial functionality. TERT has been shown to act independently of TERC in the Wnt-?-catenin signaling pathway, regulating the expression of Wnt target genes, which play a role in development and tumorigenesis. Moreover, TERT RNA-dependent RNA poly- merase activity has been found, leading to the genesis of double-stranded RNAs that act as precursor of silencing RNAs. In mitochondria, a TERT TERC-independent reverse transcriptase activity has been described that could play a role in the protection of mito- chondrial integrity. In this review, we will discuss some of the extra-telomeric functions of telomerase. (literal)
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