http://www.cnr.it/ontology/cnr/individuo/prodotto/ID198132
Exploitation of beta-glycosyl azides for the preparation of alpha-glycosynthases, (Articolo in rivista)
- Type
- Label
- Exploitation of beta-glycosyl azides for the preparation of alpha-glycosynthases, (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.3109/10242422.2012.679814 (literal)
- Alternative label
Beatrice Cobucci-Ponzano1, Carmela Zorzetti1, Andrea Strazzulli1, Emiliano Bedini2, Maria Michela Corsaro2, Gerlind Sulzenbacher3, Mosè Rossi1 & Marco Moracci1 (2012)
Exploitation of beta-glycosyl azides for the preparation of alpha-glycosynthases,
in Biocatalysis and biotransformation (Online)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Beatrice Cobucci-Ponzano1, Carmela Zorzetti1, Andrea Strazzulli1, Emiliano Bedini2, Maria Michela Corsaro2, Gerlind Sulzenbacher3, Mosè Rossi1 & Marco Moracci1 (literal)
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- 1. Institute of Protein Biochemistry Consiglio Nazionale delle Ricerche, Naples, Italy
2. Dipartimento di Chimica Organica e Biochimica, Universitá di Napoli Federico II, Complesso Universitario di Monte S. Angelo, Napoli, Italy
3. Architecture et Fonction des Macromolécules Biologiques, UMR6098 CNRS, Université de Provence, Université de la Méditerranée, Marseille cedex 9, France (literal)
- Titolo
- Exploitation of beta-glycosyl azides for the preparation of alpha-glycosynthases, (literal)
- Abstract
- An interesting approach for the chemo-enzymatic synthesis of carbohydrates is the use of glycosynthases, a class of mutant glycosidases derived from ?-glycoside hydrolases obtained by replacement of the active site nucleophile with a non-nucleophilic residue. However, the scarcity of ?-glycosynthases has so far hampered access to the synthesis of a large class of oligosaccharides of biotechnological interest. We review here a new glycosynthetic methodology for the production of two retaining ?-fucosynthases and an ?-galactosynthase exploiting ?-glycosyl azide derivatives. The general applicability of this approach, which opens new perspectives in the use of azide derivatives for the production of novel ?-glycosynthases, is discussed. (literal)
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