http://www.cnr.it/ontology/cnr/individuo/prodotto/ID197998
Characterisation of a label-free biosensor based on long period grating (Articolo in rivista)
- Type
- Label
- Characterisation of a label-free biosensor based on long period grating (Articolo in rivista) (literal)
- Anno
- 2014-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/jbio.201200135 (literal)
- Alternative label
F.Chiavaioli, C.Trono, A.Giannetti, M.Brenci, F.Baldini (2014)
Characterisation of a label-free biosensor based on long period grating
in Journal of biophotonics (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- F.Chiavaioli, C.Trono, A.Giannetti, M.Brenci, F.Baldini (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- IFAC-CNR, Sesto Fiorentino, Firenze (literal)
- Titolo
- Characterisation of a label-free biosensor based on long period grating (literal)
- Abstract
- Optical fibre gratings, especially long period gratings, have been recently proposed as optical devices for biochemical sensing. A biochemical interaction along the grating portion induces a refractive index change and
hence a change in the fiber transmission spectrum. This provides an alternative methodology with respect to
other label-free optical approaches, such as surface plasmon resonance, interferometric configurations and optical resonators. The fibre biofunctionalization has been carried out by means of a novel chemistry using Eudragit L100 copolymer as opposed to the commonly used silanization procedure. Antigen-antibody interaction has been analysed by means of an IgG/anti-IgG bioassay. The biosensor was fully characterised, monitoring the kinetics during the antibody immobilization and the antigen interaction and achieving the calibration curve of
the assay. A comparison of the biosensor performance was made by using two different long period gratings with distinct periods.
Sketch of the proposed biosensor based on a long period grating. After the deposition of the biolayer, the
interaction between the coupled cladding mode and the surrounding environment causes a refractive index
change of the layer. The enlargement details the composition of the biolayer. (literal)
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