http://www.cnr.it/ontology/cnr/individuo/prodotto/ID19789
EDM-DEDM and protein crystal structure solution (Articolo in rivista)
- Type
- Label
- EDM-DEDM and protein crystal structure solution (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1107/S0907444909008609 (literal)
- Alternative label
Caliandro R., Carrozzini B., Cascarano G.L., Giacovazzo C., Mazzone A.M., Siliqi D. (2009)
EDM-DEDM and protein crystal structure solution
in Acta crystallographica. Section D, Biological crystallography.
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Caliandro R., Carrozzini B., Cascarano G.L., Giacovazzo C., Mazzone A.M., Siliqi D. (literal)
- Pagina inizio
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Titolo
- EDM-DEDM and protein crystal structure solution (literal)
- Abstract
- Electron-density modification (EDM) procedures are the classical tool for driving model phases closer to those of the target structure. They are often combined with automated model-building programs to provide a correct protein model. The task is not always performed, mostly because of the large initial phase error. A recently proposed procedure combined EDM with DEDM (difference electron-density modification); the method was applied to the refinement of phases obtained by molecular replacement, ab initio or SAD phasing [Caliandro, Carrozzini, Cascarano, Giacovazzo, Mazzone & Siliqi (2009), Acta Cryst. D65, 249-256] and was more effective in improving phases than EDM alone. In this paper, a novel fully automated protocol for protein structure refinement based on the iterative application of automated model-building programs combined with the additional power derived from the EDM-DEDM algorithm is presented. The cyclic procedure was successfully tested on challenging cases for which all other approaches had failed. (literal)
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