Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense. (Articolo in rivista)

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  • Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense. (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bmcl.2012.09.065. (literal)
Alternative label
  • Daniela Vullo a, Viviana De Luca b, Andrea Scozzafava a, Vincenzo Carginale b, Mosè Rossi b, c, Claudiu T. Supuran a, d, Clemente Capasso b (2012)
    Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.
    in Bioorganic and medicinal chemistry letters (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Daniela Vullo a, Viviana De Luca b, Andrea Scozzafava a, Vincenzo Carginale b, Mosè Rossi b, c, Claudiu T. Supuran a, d, Clemente Capasso b (literal)
Pagina inizio
  • 7142 (literal)
Pagina fine
  • 7145 (literal)
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  • http://www.sciencedirect.com/science/article/pii/S0960894X12012206 (literal)
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  • 22 (literal)
Rivista
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  • 4 (literal)
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  • 23 (literal)
Note
  • PubMe (literal)
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  • a Università degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, 50019 Sesto Fiorentino (Florence), Italy b Istituto di Biochimica delle Proteine-CNR, Via P. Castellino 111, 80131 Napoli, Italy c Centro di Ricerca Interdipartimentale sui Biomateriali, Università Federico II, P-le V. Tecchio 80, 80125 Napoli, Italy d Università degli Studi di Firenze, Polo Scientifico, Dipartimento di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy (literal)
Titolo
  • Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense. (literal)
Abstract
  • The ?-carbonic anhydrase (CA, EC 4.2.1.1) from the extremophilic bacterium Sulfurihydrogenibium azorense, SazCA, is the fastest CA known to date as a catalyst for CO2 hydration to bicarbonate and protons. We report an inhibition study of this enzyme with inorganic anions and several other small molecules known to interact with these metalloenzymes. Bicarbonate, carbonate and sulfate were ineffective SazCA inhibitors whereas most other inorganic anions were submillimolar inhibitors. The best inhibition was observed with trithiocarbonate, diethyldithiocarbamate, sulfamide, sulfamate, phenylboronic, and phenylarsonic acid, which showed inhibition constants in the range of 3-39 ?M. As SazCA is very stable at high temperatures (being an 'extremo-CA') and very effective as a catalyst, the inhibition studies reported here may be crucial for designing biotechnological applications for this enzyme, for example for CO2 capture processes. (literal)
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