Anion inhibition studies of an ?-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1. (Articolo in rivista)

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Label
  • Anion inhibition studies of an ?-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1. (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bmcl.2012.06.106 (literal)
Alternative label
  • Viviana De Luca a, Daniela Vullo b, Andrea Scozzafava b, Vincenzo Carginale a, Mosè Rossi a, c, Claudiu T. Supuran b, d, Clemente Capasso a, (2012)
    Anion inhibition studies of an ?-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1.
    in Bioorganic and medicinal chemistry letters (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Viviana De Luca a, Daniela Vullo b, Andrea Scozzafava b, Vincenzo Carginale a, Mosè Rossi a, c, Claudiu T. Supuran b, d, Clemente Capasso a, (literal)
Pagina inizio
  • 5630 (literal)
Pagina fine
  • 5634 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.sciencedirect.com/science/article/pii/S0960894X12008669 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 22 (literal)
Rivista
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  • 17 (literal)
Note
  • PubMe (literal)
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  • a Istituto di Biochimica delle Proteine--CNR, Via P. Castellino 111, 80131 Napoli, Italy b Università degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, 50019 Sesto Fiorentino (Florence), Italy c Centro di Ricerca Interdipartimentale sui Biomateriali, Univ. Federico II, P-le V. Tecchio 80, 80125 Napoli, Italy d Università degli Studi di Firenze, Polo Scientifico, Dipartimento di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy (literal)
Titolo
  • Anion inhibition studies of an ?-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1. (literal)
Abstract
  • The newly discovered thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 encodes an ?-carbonic anhydrases (CAs, EC 4.2.1.1) which is highly catalytically active and thermostable. Here we report the inhibition of this enzyme, denominated SspCA, with inorganic and complex anions and other molecules interacting with zinc proteins. SspCA was inhibited in the micromolar range by diethyldithiocarbamate, sulfamide, sulfamic acid, phenylboronic and phenylarsonic acid, trithiocarbonate and selenocyanide (KIs of 4-70 ?M) and in the submillimolar one by iodide, cyanide, (thio)cyanate, hydrogen sulfide, azide, nitrate, nitrite, many complex anions incorporating heavy metal ions and iminodisulfonate (KIs of 0.48-0.86 mM). SspCA was not substantially inhibited by bicarbonate and carbonate, hydrogensulfite and peroxidisulfate (KIs in the range of 21.1-84.6 mM). The exceptional thermostability and lack of strong affinity for hydrogensulfide, bicarbonate, and carbonate make this enzyme an interesting candidate for biotechnological applications of enzymatic CO2 fixation. (literal)
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